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Real-Time insight into in vivo redox status utilizing hyperpolarized [1-13C] N-acetyl cysteine.
Yamamoto K, Opina A, Sail D, Blackman B, Saito K, Brender JR, Malinowski RM, Seki T, Oshima N, Crooks DR, Kishimoto S, Saida Y, Otowa Y, Choyke PL, Ardenkjær-Larsen JH, Mitchell JB, Linehan WM, Swenson RE, Krishna MC. Yamamoto K, et al. Among authors: oshima n. Sci Rep. 2021 Jun 9;11(1):12155. doi: 10.1038/s41598-021-90921-0. Sci Rep. 2021. PMID: 34108512 Free PMC article.
Dynamic Imaging of Glucose and Lactate Metabolism by 13C-MRS without Hyperpolarization.
Brender JR, Kishimoto S, Merkle H, Reed G, Hurd RE, Chen AP, Ardenkjaer-Larsen JH, Munasinghe J, Saito K, Seki T, Oshima N, Yamamoto K, Choyke PL, Mitchell J, Krishna MC. Brender JR, et al. Among authors: oshima n. Sci Rep. 2019 Mar 4;9(1):3410. doi: 10.1038/s41598-019-38981-1. Sci Rep. 2019. PMID: 30833588 Free PMC article.
Imaging of glucose metabolism by 13C-MRI distinguishes pancreatic cancer subtypes in mice.
Kishimoto S, Brender JR, Crooks DR, Matsumoto S, Seki T, Oshima N, Merkle H, Lin P, Reed G, Chen AP, Ardenkjaer-Larsen JH, Munasinghe J, Saito K, Yamamoto K, Choyke PL, Mitchell J, Lane AN, Fan TW, Linehan WM, Krishna MC. Kishimoto S, et al. Among authors: oshima n. Elife. 2019 Aug 13;8:e46312. doi: 10.7554/eLife.46312. Elife. 2019. PMID: 31408004 Free PMC article.
Molecular Imaging of the Tumor Microenvironment Reveals the Relationship between Tumor Oxygenation, Glucose Uptake, and Glycolysis in Pancreatic Ductal Adenocarcinoma.
Yamamoto K, Brender JR, Seki T, Kishimoto S, Oshima N, Choudhuri R, Adler SS, Jagoda EM, Saito K, Devasahayam N, Choyke PL, Mitchell JB, Krishna MC. Yamamoto K, et al. Among authors: oshima n. Cancer Res. 2020 Jun 1;80(11):2087-2093. doi: 10.1158/0008-5472.CAN-19-0928. Epub 2020 Apr 3. Cancer Res. 2020. PMID: 32245793 Free PMC article.
Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy.
Oshima N, Ishida R, Kishimoto S, Beebe K, Brender JR, Yamamoto K, Urban D, Rai G, Johnson MS, Benavides G, Squadrito GL, Crooks D, Jackson J, Joshi A, Mott BT, Shrimp JH, Moses MA, Lee MJ, Yuno A, Lee TD, Hu X, Anderson T, Kusewitt D, Hathaway HH, Jadhav A, Picard D, Trepel JB, Mitchell JB, Stott GM, Moore W, Simeonov A, Sklar LA, Norenberg JP, Linehan WM, Maloney DJ, Dang CV, Waterson AG, Hall M, Darley-Usmar VM, Krishna MC, Neckers LM. Oshima N, et al. Cell Rep. 2020 Feb 11;30(6):1798-1810.e4. doi: 10.1016/j.celrep.2020.01.039. Cell Rep. 2020. PMID: 32049011 Free PMC article.
Structure-guided design enables development of a hyperpolarized molecular probe for the detection of aminopeptidase N activity in vivo.
Saito Y, Yatabe H, Tamura I, Kondo Y, Ishida R, Seki T, Hiraga K, Eguchi A, Takakusagi Y, Saito K, Oshima N, Ishikita H, Yamamoto K, Krishna MC, Sando S. Saito Y, et al. Among authors: oshima n. Sci Adv. 2022 Apr;8(13):eabj2667. doi: 10.1126/sciadv.abj2667. Epub 2022 Mar 30. Sci Adv. 2022. PMID: 35353577 Free PMC article.
495 results