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Cerebrospinal fluid hemoglobin drives subarachnoid hemorrhage-related secondary brain injury.
Akeret K, Buzzi RM, Schaer CA, Thomson BR, Vallelian F, Wang S, Willms J, Sebök M, Held U, Deuel JW, Humar R, Regli L, Keller E, Hugelshofer M, Schaer DJ. Akeret K, et al. Among authors: schaer dj, schaer ca. J Cereb Blood Flow Metab. 2021 Nov;41(11):3000-3015. doi: 10.1177/0271678X211020629. Epub 2021 Jun 8. J Cereb Blood Flow Metab. 2021. PMID: 34102922 Free PMC article.
The reaction of hydrogen peroxide with hemoglobin induces extensive alpha-globin crosslinking and impairs the interaction of hemoglobin with endogenous scavenger pathways.
Vallelian F, Pimenova T, Pereira CP, Abraham B, Mikolajczyk MG, Schoedon G, Zenobi R, Alayash AI, Buehler PW, Schaer DJ. Vallelian F, et al. Among authors: schaer dj. Free Radic Biol Med. 2008 Oct 15;45(8):1150-8. doi: 10.1016/j.freeradbiomed.2008.07.013. Epub 2008 Jul 27. Free Radic Biol Med. 2008. PMID: 18708138
115 results