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Genetically Encoded, pH-Sensitive mTFP1 Biosensor for Probing Lysosomal pH.
Chin MY, Patwardhan AR, Ang KH, Wang AL, Alquezar C, Welch M, Nguyen PT, Grabe M, Molofsky AV, Arkin MR, Kao AW. Chin MY, et al. Among authors: kao aw. ACS Sens. 2021 Jun 25;6(6):2168-2180. doi: 10.1021/acssensors.0c02318. Epub 2021 Jun 8. ACS Sens. 2021. PMID: 34102054 Free PMC article.
Linking tuberous sclerosis complex, excessive mTOR signaling, and age-related neurodegeneration: a new association between TSC1 mutation and frontotemporal dementia.
Olney NT, Alquezar C, Ramos EM, Nana AL, Fong JC, Karydas AM, Taylor JB, Stephens ML, Argouarch AR, Van Berlo VA, Dokuru DR, Sherr EH, Jicha GA, Dillon WP, Desikan RS, De May M, Seeley WW, Coppola G, Miller BL, Kao AW. Olney NT, et al. Among authors: kao aw. Acta Neuropathol. 2017 Nov;134(5):813-816. doi: 10.1007/s00401-017-1764-0. Epub 2017 Aug 21. Acta Neuropathol. 2017. PMID: 28828560 Free PMC article. No abstract available.
Protons in small spaces: Discrete simulations of vesicle acidification.
Singh A, Marcoline FV, Veshaguri S, Kao AW, Bruchez M, Mindell JA, Stamou D, Grabe M. Singh A, et al. Among authors: kao aw. PLoS Comput Biol. 2019 Dec 23;15(12):e1007539. doi: 10.1371/journal.pcbi.1007539. eCollection 2019 Dec. PLoS Comput Biol. 2019. PMID: 31869334 Free PMC article.
Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration.
Mohan S, Sampognaro PJ, Argouarch AR, Maynard JC, Welch M, Patwardhan A, Courtney EC, Zhang J, Mason A, Li KH, Huang EJ, Seeley WW, Miller BL, Burlingame A, Jacobson MP, Kao AW. Mohan S, et al. Among authors: kao aw. Mol Neurodegener. 2021 Aug 3;16(1):51. doi: 10.1186/s13024-021-00472-1. Mol Neurodegener. 2021. PMID: 34344440 Free PMC article.
TSC1 loss increases risk for tauopathy by inducing tau acetylation and preventing tau clearance via chaperone-mediated autophagy.
Alquezar C, Schoch KM, Geier EG, Ramos EM, Scrivo A, Li KH, Argouarch AR, Mlynarski EE, Dombroski B, DeTure M, Dickson DW, Yokoyama JS, Cuervo AM, Burlingame AL, Schellenberg GD, Miller TM, Miller BL, Kao AW. Alquezar C, et al. Among authors: kao aw. Sci Adv. 2021 Nov 5;7(45):eabg3897. doi: 10.1126/sciadv.abg3897. Epub 2021 Nov 5. Sci Adv. 2021. PMID: 34739309 Free PMC article.
Tuberous sclerosis complex is associated with a novel human tauopathy.
Hwang JL, Perloff OS, Gaus SE, Benitez C, Alquezar C, Cosme CQ, Nana AL, Vatsavayai SC, Ramos EM, Geschwind DH, Miller BL, Kao AW, Seeley WW. Hwang JL, et al. Among authors: kao aw. Acta Neuropathol. 2023 Jan;145(1):1-12. doi: 10.1007/s00401-022-02521-5. Epub 2022 Dec 5. Acta Neuropathol. 2023. PMID: 36469115 Free PMC article.
72 results