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The brain penetrant PPARγ agonist leriglitazone restores multiple altered pathways in models of X-linked adrenoleukodystrophy.
Rodríguez-Pascau L, Vilalta A, Cerrada M, Traver E, Forss-Petter S, Weinhofer I, Bauer J, Kemp S, Pina G, Pascual S, Meya U, Musolino PL, Berger J, Martinell M, Pizcueta P. Rodríguez-Pascau L, et al. Among authors: pascual s. Sci Transl Med. 2021 Jun 2;13(596):eabc0555. doi: 10.1126/scitranslmed.abc0555. Sci Transl Med. 2021. PMID: 34078742
Efficacy and Safety of Leriglitazone in Patients With Friedreich Ataxia: A Phase 2 Double-Blind, Randomized Controlled Trial (FRAMES).
Pandolfo M, Reetz K, Darling A, Rodriguez de Rivera FJ, Henry PG, Joers J, Lenglet C, Adanyeguh I, Deelchand D, Mochel F, Pousset F, Pascual S, Van den Eede D, Martin-Ugarte I, Vilà-Brau A, Mantilla A, Pascual M, Martinell M, Meya U, Durr A. Pandolfo M, et al. Among authors: pascual m, pascual s. Neurol Genet. 2022 Nov 1;8(6):e200034. doi: 10.1212/NXG.0000000000200034. eCollection 2022 Dec. Neurol Genet. 2022. PMID: 36524101 Free PMC article.
Safety and efficacy of leriglitazone for preventing disease progression in men with adrenomyeloneuropathy (ADVANCE): a randomised, double-blind, multi-centre, placebo-controlled phase 2-3 trial.
Köhler W, Engelen M, Eichler F, Lachmann R, Fatemi A, Sampson J, Salsano E, Gamez J, Molnar MJ, Pascual S, Rovira M, Vilà A, Pina G, Martín-Ugarte I, Mantilla A, Pizcueta P, Rodríguez-Pascau L, Traver E, Vilalta A, Pascual M, Martinell M, Meya U, Mochel F; ADVANCE Study Group. Köhler W, et al. Among authors: pascual m, pascual s. Lancet Neurol. 2023 Feb;22(2):127-136. doi: 10.1016/S1474-4422(22)00495-1. Lancet Neurol. 2023. PMID: 36681445 Clinical Trial.
Clinical pharmacokinetics of leriglitazone and a translational approach using PBPK modeling to guide the selection of the starting dose in children.
Traver E, Rodríguez-Pascau L, Meya U, Pina G, Pascual S, Poli S, Eckland D, van de Wetering J, Ke A, Lindauer A, Martinell M, Pizcueta P. Traver E, et al. Among authors: pascual s. CPT Pharmacometrics Syst Pharmacol. 2024 Mar 29. doi: 10.1002/psp4.13132. Online ahead of print. CPT Pharmacometrics Syst Pharmacol. 2024. PMID: 38549500 Free article.
Potential value of a rapid syndromic multiplex PCR for the diagnosis of native and prosthetic joint infections: a real-world evidence study.
Pascual S, Noble B, Ahmad-Saeed N, Aldridge C, Ambretti S, Amit S, Annett R, O'Shea SA, Barbui AM, Barlow G, Barrett L, Berth M, Bondi A, Boran N, Boyd SE, Chaves C, Clauss M, Davies P, Dianzo-Delgado IT, Esteban J, Fuchs S, Friis-Hansen L, Goldenberger D, Golle A, Groonroos JO, Hoffmann I, Hoffmann T, Hughes H, Ivanova M, Jezek P, Jones G, Ceren Karahan Z, Lass-Flörl C, Laurent F, Leach L, Horsbøll Pedersen ML, Loiez C, Lynch M, Maloney RJ, Marsh M, Milburn O, Mitchell S, Moore LSP, Moffat L, Murdjeva M, Murphy ME, Nayar D, Nigrisoli G, O'Sullivan F, Öz B, Peach T, Petridou C, Prinz M, Rak M, Reidy N, Rossolini GM, Roux AL, Ruiz-Garbajosa P, Saeed K, Salar-Vidal L, Salas Venero C, Selvaratnam M, Senneville E, Starzengruber P, Talbot B, Taylor V, Trebše R, Wearmouth D, Willinger B, Wouthuyzen-Bakker M, Couturier B, Allantaz F. Pascual S, et al. J Bone Jt Infect. 2024 Feb 28;9(1):87-97. doi: 10.5194/jbji-9-87-2024. eCollection 2024. J Bone Jt Infect. 2024. PMID: 38601005 Free PMC article.
Primary Sclerosing Cholangitis: Gender Effects in Valencia's Low-Prevalence Region.
Mínguez A, Conde I, Montón C, Gonzalez L, Pascual S, Antón MD, Palau A, Forés A, Gisbert C, Ojeda A, Girona E, Di Maira T, Berenguer M. Mínguez A, et al. Among authors: pascual s. Dig Dis Sci. 2024 May;69(5):1863-1871. doi: 10.1007/s10620-024-08368-y. Epub 2024 Mar 22. Dig Dis Sci. 2024. PMID: 38517562
263 results