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Simeprevir Potently Suppresses SARS-CoV-2 Replication and Synergizes with Remdesivir.
Lo HS, Hui KPY, Lai HM, He X, Khan KS, Kaur S, Huang J, Li Z, Chan AKN, Cheung HH, Ng KC, Ho JCW, Chen YW, Ma B, Cheung PM, Shin D, Wang K, Lee MH, Selisko B, Eydoux C, Guillemot JC, Canard B, Wu KP, Liang PH, Dikic I, Zuo Z, Chan FKL, Hui DSC, Mok VCT, Wong KB, Mok CKP, Ko H, Aik WS, Chan MCW, Ng WL. Lo HS, et al. Among authors: ho jcw. ACS Cent Sci. 2021 May 26;7(5):792-802. doi: 10.1021/acscentsci.0c01186. Epub 2021 Apr 15. ACS Cent Sci. 2021. PMID: 34075346 Free PMC article.
Amino acid substitution L232F in non-structural protein 6 identified as a possible human-adaptive mutation in clade B MERS coronaviruses.
So RTY, Chu DKW, Hui KPY, Mok CKP, Shum MHH, Sanyal S, Nicholls JM, Ho JCW, Cheung M-c, Ng K-c, Yeung H-W, Chan MCW, Poon LLM, Zhao J, Lam TTY, Peiris M. So RTY, et al. Among authors: ho jcw. J Virol. 2023 Dec 21;97(12):e0136923. doi: 10.1128/jvi.01369-23. Epub 2023 Dec 1. J Virol. 2023. PMID: 38038429 Free PMC article.
Mutation nsp6 L232F associated with MERS-CoV zoonotic transmission confers higher viral replication in human respiratory tract cultures ex-vivo.
So RT, Chu DK, Hui KP, Mok CK, Sanyal S, Nicholls JM, Ho JCW, Cheung MC, Ng KC, Yeung HW, Chan MC, Poon LL, Zhao J, Peiris M. So RT, et al. Among authors: ho jcw. bioRxiv [Preprint]. 2023 Mar 28:2023.03.27.534490. doi: 10.1101/2023.03.27.534490. bioRxiv. 2023. PMID: 37034576 Free PMC article. Updated. Preprint.
22 results