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Therapeutics Targeting the Core Apoptotic Machinery.
Hamilton C, Fox JP, Longley DB, Higgins CA. Hamilton C, et al. Among authors: higgins ca. Cancers (Basel). 2021 May 26;13(11):2618. doi: 10.3390/cancers13112618. Cancers (Basel). 2021. PMID: 34073507 Free PMC article. Review.
FLIP: A Targetable Mediator of Resistance to Radiation in Non-Small Cell Lung Cancer.
McLaughlin KA, Nemeth Z, Bradley CA, Humphreys L, Stasik I, Fenning C, Majkut J, Higgins C, Crawford N, Holohan C, Johnston PG, Harrison T, Hanna GG, Butterworth KT, Prise KM, Longley DB. McLaughlin KA, et al. Among authors: higgins c. Mol Cancer Ther. 2016 Oct;15(10):2432-2441. doi: 10.1158/1535-7163.MCT-16-0211. Epub 2016 Jul 29. Mol Cancer Ther. 2016. PMID: 27474150
The SCFSkp2 ubiquitin ligase complex modulates TRAIL-R2-induced apoptosis by regulating FLIP(L).
Roberts JZ, Holohan C, Sessler T, Fox J, Crawford N, Riley JS, Khawaja H, Majkut J, Evergren E, Humphreys LM, Ferris J, Higgins C, Espona-Fiedler M, Moynagh P, McDade SS, Longley DB. Roberts JZ, et al. Cell Death Differ. 2020 Sep;27(9):2726-2741. doi: 10.1038/s41418-020-0539-7. Epub 2020 Apr 20. Cell Death Differ. 2020. PMID: 32313199 Free PMC article.
TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities.
D'Costa ZC, Higgins C, Ong CW, Irwin GW, Boyle D, McArt DG, McCloskey K, Buckley NE, Crawford NT, Thiagarajan L, Murray JT, Kennedy RD, Mulligan KA, Harkin DP, Waugh DJ, Scott CJ, Salto-Tellez M, Williams R, Mullan PB. D'Costa ZC, et al. Oncotarget. 2014 Mar 30;5(6):1609-20. doi: 10.18632/oncotarget.1707. Oncotarget. 2014. PMID: 24742492 Free PMC article.
P3 SAR exploration of biphenyl carbamate based Legumain inhibitors.
Higgins C, Bouazzaoui S, Gaddale K, D'Costa Z, Templeman A, O'Rourke M, Young A, Scott C, Harrison T, Mullan P, Williams R. Higgins C, et al. Bioorg Med Chem Lett. 2014 Jun 1;24(11):2521-4. doi: 10.1016/j.bmcl.2014.04.002. Epub 2014 Apr 12. Bioorg Med Chem Lett. 2014. PMID: 24775305
Development of a potent and selective cell penetrant Legumain inhibitor.
Ness KA, Eddie SL, Higgins CA, Templeman A, D'Costa Z, Gaddale KK, Bouzzaoui S, Jordan L, Janssen D, Harrison T, Burkamp F, Young A, Burden R, Scott CJ, Mullan PB, Williams R. Ness KA, et al. Among authors: higgins ca. Bioorg Med Chem Lett. 2015 Dec 1;25(23):5642-5. doi: 10.1016/j.bmcl.2015.10.001. Epub 2015 Oct 9. Bioorg Med Chem Lett. 2015. PMID: 26522952
92 results