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Page 1
New Coumarin Derivatives as Cholinergic and Cannabinoid System Modulators.
Montanari S, Allarà M, Scalvini L, Kostrzewa M, Belluti F, Gobbi S, Naldi M, Rivara S, Bartolini M, Ligresti A, Bisi A, Rampa A. Montanari S, et al. Among authors: kostrzewa m. Molecules. 2021 May 28;26(11):3254. doi: 10.3390/molecules26113254. Molecules. 2021. PMID: 34071439 Free PMC article.
Design, Synthesis, and Physicochemical and Pharmacological Profiling of 7-Hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide Derivatives with Antiosteoarthritic Activity In Vivo.
Mugnaini C, Kostrzewa M, Bryk M, Mahmoud AM, Brizzi A, Lamponi S, Giorgi G, Ferlenghi F, Vacondio F, Maccioni P, Colombo G, Mor M, Starowicz K, Di Marzo V, Ligresti A, Corelli F. Mugnaini C, et al. Among authors: kostrzewa m. J Med Chem. 2020 Jul 9;63(13):7369-7391. doi: 10.1021/acs.jmedchem.0c00595. Epub 2020 Jun 22. J Med Chem. 2020. PMID: 32515588
Synthesis of the Major Mammalian Metabolites of THCV.
Tinto F, Villano R, Kostrzewa M, Ligresti A, Straker H, Manzo E. Tinto F, et al. Among authors: kostrzewa m. J Nat Prod. 2020 Jul 24;83(7):2060-2065. doi: 10.1021/acs.jnatprod.9b00831. Epub 2020 Jul 10. J Nat Prod. 2020. PMID: 32649196
Biosynthesis of the Novel Endogenous 15-Lipoxygenase Metabolites N-13-Hydroxy-octodecadienoyl-ethanolamine and 13-Hydroxy-octodecadienoyl-glycerol by Human Neutrophils and Eosinophils.
Archambault AS, Tinto F, Dumais É, Rakotoarivelo V, Kostrzewa M, Plante PL, Martin C, Simard M, Silvestri C, Pouliot R, Laviolette M, Boulet LP, Vitale RM, Ligresti A, Di Marzo V, Flamand N. Archambault AS, et al. Among authors: kostrzewa m. Cells. 2021 Sep 5;10(9):2322. doi: 10.3390/cells10092322. Cells. 2021. PMID: 34571971 Free PMC article.
N-[1,3-Dialkyl(aryl)-2-oxoimidazolidin-4-ylidene]-aryl(alkyl)sulphonamides as Novel Selective Human Cannabinoid Type 2 Receptor (hCB2R) Ligands; Insights into the Mechanism of Receptor Activation/Deactivation.
Gianquinto E, Sodano F, Rolando B, Kostrzewa M, Allarà M, Mahmoud AM, Kumar P, Spyrakis F, Ligresti A, Chegaev K. Gianquinto E, et al. Among authors: kostrzewa m. Molecules. 2022 Nov 23;27(23):8152. doi: 10.3390/molecules27238152. Molecules. 2022. PMID: 36500256 Free PMC article.
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase.
Intranuovo F, Brunetti L, DelRe P, Mangiatordi GF, Stefanachi A, Laghezza A, Niso M, Leonetti F, Loiodice F, Ligresti A, Kostrzewa M, Brea J, Loza MI, Sotelo E, Saviano M, Colabufo NA, Riganti C, Abate C, Contino M. Intranuovo F, et al. Among authors: kostrzewa m. J Med Chem. 2023 Jan 12;66(1):235-250. doi: 10.1021/acs.jmedchem.2c01084. Epub 2022 Dec 21. J Med Chem. 2023. PMID: 36542836
N-adamantyl-anthranil amide derivatives: New selective ligands for the cannabinoid receptor subtype 2 (CB2R).
Graziano G, Delre P, Carofiglio F, Brea J, Ligresti A, Kostrzewa M, Riganti C, Gioè-Gallo C, Majellaro M, Nicolotti O, Colabufo NA, Abate C, Loza MI, Sotelo E, Mangiatordi GF, Contino M, Stefanachi A, Leonetti F. Graziano G, et al. Among authors: kostrzewa m. Eur J Med Chem. 2023 Feb 15;248:115109. doi: 10.1016/j.ejmech.2023.115109. Epub 2023 Jan 13. Eur J Med Chem. 2023. PMID: 36657299
Systematic Modification of the Substitution Pattern of the 7-Hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide Scaffold Enabled the Discovery of New Ligands with High Affinity and Selectivity for the Cannabinoid Type 2 Receptor.
Mugnaini C, Kostrzewa M, Casini M, Kumar P, Catallo V, Allarà M, Guastaferro L, Brizzi A, Paolino M, Tafi A, Kapatais C, Giorgi G, Vacondio F, Mor M, Corelli F, Ligresti A. Mugnaini C, et al. Among authors: kostrzewa m. Molecules. 2023 Jun 24;28(13):4958. doi: 10.3390/molecules28134958. Molecules. 2023. PMID: 37446625 Free PMC article.
Novel Dual-Acting Hybrids Targeting Type-2 Cannabinoid Receptors and Cholinesterase Activity Show Neuroprotective Effects In Vitro and Amelioration of Cognitive Impairment In Vivo.
Mugnaini C, Brizzi A, Paolino M, Scarselli E, Castelli R, de Candia M, Gambacorta N, Nicolotti O, Kostrzewa M, Kumar P, Mahmoud AM, Borgonetti V, Iannotta M, Morace A, Galeotti N, Maione S, Altomare CD, Ligresti A, Corelli F. Mugnaini C, et al. Among authors: kostrzewa m. ACS Chem Neurosci. 2024 Mar 6;15(5):955-971. doi: 10.1021/acschemneuro.3c00656. Epub 2024 Feb 19. ACS Chem Neurosci. 2024. PMID: 38372253
258 results