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Targeting Mcl-1 for multiple myeloma (MM) therapy: drug-induced generation of Mcl-1 fragment Mcl-1(128-350) triggers MM cell death via c-Jun upregulation.
Fan F, Tonon G, Bashari MH, Vallet S, Antonini E, Goldschmidt H, Schulze-Bergkamen H, Opferman JT, Sattler M, Anderson KC, Jäger D, Podar K. Fan F, et al. Among authors: podar k. Cancer Lett. 2014 Feb 28;343(2):286-94. doi: 10.1016/j.canlet.2013.09.042. Epub 2013 Oct 8. Cancer Lett. 2014. PMID: 24120758
The AP-1 transcription factor JunB is essential for multiple myeloma cell proliferation and drug resistance in the bone marrow microenvironment.
Fan F, Bashari MH, Morelli E, Tonon G, Malvestiti S, Vallet S, Jarahian M, Seckinger A, Hose D, Bakiri L, Sun C, Hu Y, Ball CR, Glimm H, Sattler M, Goldschmidt H, Wagner EF, Tassone P, Jaeger D, Podar K. Fan F, et al. Among authors: podar k. Leukemia. 2017 Jul;31(7):1570-1581. doi: 10.1038/leu.2016.358. Epub 2016 Nov 28. Leukemia. 2017. PMID: 27890927
Inhibitors of the Transcription Factor STAT3 Decrease Growth and Induce Immune Response Genes in Models of Malignant Pleural Mesothelioma (MPM).
Lapidot M, Case AE, Larios D, Gandler HI, Meng C, Tošić I, Weisberg EL, Poitras MJ, Gokhale PC, Paweletz CP, Podar K, Salgia R, Saladi SV, Griffin JD, Frank DA, Bueno R, Sattler M. Lapidot M, et al. Among authors: podar k. Cancers (Basel). 2020 Dec 22;13(1):7. doi: 10.3390/cancers13010007. Cancers (Basel). 2020. PMID: 33374980 Free PMC article.
Pathway-Directed Therapy in Multiple Myeloma.
John L, Krauth MT, Podar K, Raab MS. John L, et al. Among authors: podar k. Cancers (Basel). 2021 Apr 1;13(7):1668. doi: 10.3390/cancers13071668. Cancers (Basel). 2021. PMID: 33916289 Free PMC article. Review.
158 results