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A Melanocortin-4 Receptor Agonist Induces Skin and Hair Pigmentation in Patients with Monogenic Mutations in the Leptin-Melanocortin Pathway.
Skin Pharmacol Physiol. 2021;34(6):307-316. doi: 10.1159/000516282. Epub 2021 May 31.
Skin Pharmacol Physiol. 2021.
PMID: 34058738
Clinical Trial.
MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency.
Clément K, Biebermann H, Farooqi IS, Van der Ploeg L, Wolters B, Poitou C, Puder L, Fiedorek F, Gottesdiener K, Kleinau G, Heyder N, Scheerer P, Blume-Peytavi U, Jahnke I, Sharma S, Mokrosinski J, Wiegand S, Müller A, Weiß K, Mai K, Spranger J, Grüters A, Blankenstein O, Krude H, Kühnen P.
Clément K, et al. Among authors: puder l.
Nat Med. 2018 May;24(5):551-555. doi: 10.1038/s41591-018-0015-9. Epub 2018 May 7.
Nat Med. 2018.
PMID: 29736023
Clinical Trial.
Item in Clipboard
Long-term outcomes of bariatric surgery in patients with bi-allelic mutations in the POMC, LEPR, and MC4R genes.
Poitou C, Puder L, Dubern B, Krabusch P, Genser L, Wiegand S, Verkindt H, Köhn A, von Schwartzenberg RJ, Flück C, Pattou F, Laville M, Kühnen P, Clément K.
Poitou C, et al. Among authors: puder l.
Surg Obes Relat Dis. 2021 Aug;17(8):1449-1456. doi: 10.1016/j.soard.2021.04.020. Epub 2021 May 8.
Surg Obes Relat Dis. 2021.
PMID: 34083135
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Efficacy and safety of setmelanotide, an MC4R agonist, in individuals with severe obesity due to LEPR or POMC deficiency: single-arm, open-label, multicentre, phase 3 trials.
Clément K, van den Akker E, Argente J, Bahm A, Chung WK, Connors H, De Waele K, Farooqi IS, Gonneau-Lejeune J, Gordon G, Kohlsdorf K, Poitou C, Puder L, Swain J, Stewart M, Yuan G, Wabitsch M, Kühnen P; Setmelanotide POMC and LEPR Phase 3 Trial Investigators.
Clément K, et al. Among authors: puder l.
Lancet Diabetes Endocrinol. 2020 Dec;8(12):960-970. doi: 10.1016/S2213-8587(20)30364-8. Epub 2020 Oct 30.
Lancet Diabetes Endocrinol. 2020.
PMID: 33137293
Clinical Trial.
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Cardiac Phenotype and Tissue Sodium Content in Adolescents With Defects in the Melanocortin System.
Puder L, Roth S, Krabusch P, Wiegand S, Opitz R, Bald M, Flück C, Schulz E, Voss E, Markó L, Linz P, Berger F, Müller DN, Kuehne T, Litt MJ, Cone RD, Kühnen P, Kelm M.
Puder L, et al.
J Clin Endocrinol Metab. 2021 Aug 18;106(9):2606-2616. doi: 10.1210/clinem/dgab368.
J Clin Endocrinol Metab. 2021.
PMID: 34036349
Free PMC article.
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Validation of computerized wheeze detection in young infants during the first months of life.
Puder LC, Fischer HS, Wilitzki S, Usemann J, Godfrey S, Schmalisch G.
Puder LC, et al.
BMC Pediatr. 2014 Oct 9;14:257. doi: 10.1186/1471-2431-14-257.
BMC Pediatr. 2014.
PMID: 25296955
Free PMC article.
Item in Clipboard
Computerized wheeze detection in young infants: comparison of signals from tracheal and chest wall sensors.
Puder LC, Wilitzki S, Bührer C, Fischer HS, Schmalisch G.
Puder LC, et al.
Physiol Meas. 2016 Dec;37(12):2170-2180. doi: 10.1088/0967-3334/37/12/2170. Epub 2016 Nov 21.
Physiol Meas. 2016.
PMID: 27869106
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Relationship between computerized wheeze detection and lung function parameters in young infants.
Fischer HS, Puder LC, Wilitzki S, Usemann J, Bührer C, Godfrey S, Schmalisch G.
Fischer HS, et al. Among authors: puder lc.
Pediatr Pulmonol. 2016 Apr;51(4):402-10. doi: 10.1002/ppul.23310. Epub 2015 Sep 11.
Pediatr Pulmonol. 2016.
PMID: 26360639
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