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Synthetic hookworm-derived peptides are potent modulators of primary human immune cell function that protect against experimental colitis in vivo.
Smallwood TB, Navarro S, Cristofori-Armstrong B, Watkins TS, Tungatt K, Ryan RYM, Haigh OL, Lutzky VP, Mulvenna JP, Rosengren KJ, Loukas A, Miles JJ, Clark RJ. Smallwood TB, et al. Among authors: watkins ts. J Biol Chem. 2021 Jul;297(1):100834. doi: 10.1016/j.jbc.2021.100834. Epub 2021 May 27. J Biol Chem. 2021. PMID: 34051231 Free PMC article.
Naive CD8⁺ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics.
Neller MA, Ladell K, McLaren JE, Matthews KK, Gostick E, Pentier JM, Dolton G, Schauenburg AJ, Koning D, Fontaine Costa AI, Watkins TS, Venturi V, Smith C, Khanna R, Miners K, Clement M, Wooldridge L, Cole DK, van Baarle D, Sewell AK, Burrows SR, Price DA, Miles JJ. Neller MA, et al. Among authors: watkins ts. Immunol Cell Biol. 2015 Aug;93(7):625-33. doi: 10.1038/icb.2015.17. Epub 2015 Mar 24. Immunol Cell Biol. 2015. PMID: 25801351 Free PMC article.
Programmed Death-1 Ligand 2-Mediated Regulation of the PD-L1 to PD-1 Axis Is Essential for Establishing CD4(+) T Cell Immunity.
Karunarathne DS, Horne-Debets JM, Huang JX, Faleiro R, Leow CY, Amante F, Watkins TS, Miles JJ, Dwyer PJ, Stacey KJ, Yarski M, Poh CM, Lee JS, Cooper MA, Rénia L, Richard D, McCarthy JS, Sharpe AH, Wykes MN. Karunarathne DS, et al. Among authors: watkins ts. Immunity. 2016 Aug 16;45(2):333-45. doi: 10.1016/j.immuni.2016.07.017. Immunity. 2016. PMID: 27533014 Free article.
Tracking the T-cell repertoire after adoptive therapy.
Watkins TS, Miles JJ. Watkins TS, et al. Clin Transl Immunology. 2017 May 5;6(5):e140. doi: 10.1038/cti.2017.16. eCollection 2017 May. Clin Transl Immunology. 2017. PMID: 28690846 Free PMC article. No abstract available.
Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry.
Miles JJ, Tan MP, Dolton G, Edwards ES, Galloway SA, Laugel B, Clement M, Makinde J, Ladell K, Matthews KK, Watkins TS, Tungatt K, Wong Y, Lee HS, Clark RJ, Pentier JM, Attaf M, Lissina A, Ager A, Gallimore A, Rizkallah PJ, Gras S, Rossjohn J, Burrows SR, Cole DK, Price DA, Sewell AK. Miles JJ, et al. Among authors: watkins ts. J Clin Invest. 2018 Apr 2;128(4):1569-1580. doi: 10.1172/JCI91512. Epub 2018 Mar 12. J Clin Invest. 2018. PMID: 29528337 Free PMC article.
T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids.
Wun KS, Reijneveld JF, Cheng TY, Ladell K, Uldrich AP, Le Nours J, Miners KL, McLaren JE, Grant EJ, Haigh OL, Watkins TS, Suliman S, Iwany S, Jimenez J, Calderon R, Tamara KL, Leon SR, Murray MB, Mayfield JA, Altman JD, Purcell AW, Miles JJ, Godfrey DI, Gras S, Price DA, Van Rhijn I, Moody DB, Rossjohn J. Wun KS, et al. Among authors: watkins ts. Nat Immunol. 2018 Apr;19(4):397-406. doi: 10.1038/s41590-018-0065-7. Epub 2018 Mar 12. Nat Immunol. 2018. PMID: 29531339 Free PMC article.
The immune checkpoint CD96 defines a distinct lymphocyte phenotype and is highly expressed on tumor-infiltrating T cells.
Lepletier A, Lutzky VP, Mittal D, Stannard K, Watkins TS, Ratnatunga CN, Smith C, McGuire HM, Kemp RA, Mukhopadhyay P, Waddell N, Smyth MJ, Dougall WC, Miles JJ. Lepletier A, et al. Among authors: watkins ts. Immunol Cell Biol. 2019 Feb;97(2):152-164. doi: 10.1111/imcb.12205. Epub 2018 Oct 17. Immunol Cell Biol. 2019. PMID: 30222899
15 results