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A method for the rational selection of drug repurposing candidates from multimodal knowledge harmonization.
Schultz B, Zaliani A, Ebeling C, Reinshagen J, Bojkova D, Lage-Rupprecht V, Karki R, Lukassen S, Gadiya Y, Ravindra NG, Das S, Baksi S, Domingo-Fernández D, Lentzen M, Strivens M, Raschka T, Cinatl J, DeLong LN, Gribbon P, Geisslinger G, Ciesek S, van Dijk D, Gardner S, Kodamullil AT, Fröhlich H, Peitsch M, Jacobs M, Hoeng J, Eils R, Claussen C, Hofmann-Apitius M. Schultz B, et al. Among authors: geisslinger g. Sci Rep. 2021 May 26;11(1):11049. doi: 10.1038/s41598-021-90296-2. Sci Rep. 2021. PMID: 34040048 Free PMC article.
Characterization of ACE Inhibitors and AT1R Antagonists with Regard to Their Effect on ACE2 Expression and Infection with SARS-CoV-2 Using a Caco-2 Cell Model.
Reus P, Schneider AK, Ulshöfer T, Henke M, Bojkova D, Cinatl J, Ciesek S, Geisslinger G, Laux V, Grättinger M, Gribbon P, Schiffmann S. Reus P, et al. Among authors: geisslinger g. Life (Basel). 2021 Aug 10;11(8):810. doi: 10.3390/life11080810. Life (Basel). 2021. PMID: 34440554 Free PMC article.
Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells.
Rothenburger T, Thomas D, Schreiber Y, Wratil PR, Pflantz T, Knecht K, Digianantonio K, Temple J, Schneider C, Baldauf HM, McLaughlin KM, Rothweiler F, Bilen B, Farmand S, Bojkova D, Costa R, Ferreirós N, Geisslinger G, Oellerich T, Xiong Y, Keppler OT, Wass MN, Michaelis M, Cinatl J Jr. Rothenburger T, et al. Among authors: geisslinger g. J Exp Clin Cancer Res. 2021 Oct 12;40(1):317. doi: 10.1186/s13046-021-02093-4. J Exp Clin Cancer Res. 2021. PMID: 34641952 Free PMC article.
The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2.
Krasemann S, Haferkamp U, Pfefferle S, Woo MS, Heinrich F, Schweizer M, Appelt-Menzel A, Cubukova A, Barenberg J, Leu J, Hartmann K, Thies E, Littau JL, Sepulveda-Falla D, Zhang L, Ton K, Liang Y, Matschke J, Ricklefs F, Sauvigny T, Sperhake J, Fitzek A, Gerhartl A, Brachner A, Geiger N, König EM, Bodem J, Franzenburg S, Franke A, Moese S, Müller FJ, Geisslinger G, Claussen C, Kannt A, Zaliani A, Gribbon P, Ondruschka B, Neuhaus W, Friese MA, Glatzel M, Pless O. Krasemann S, et al. Among authors: geisslinger g. Stem Cell Reports. 2022 Feb 8;17(2):307-320. doi: 10.1016/j.stemcr.2021.12.011. Epub 2022 Jan 20. Stem Cell Reports. 2022. PMID: 35063125 Free PMC article.
Identification of Inhibitors of SARS-CoV-2 3CL-Pro Enzymatic Activity Using a Small Molecule in Vitro Repurposing Screen.
Kuzikov M, Costanzi E, Reinshagen J, Esposito F, Vangeel L, Wolf M, Ellinger B, Claussen C, Geisslinger G, Corona A, Iaconis D, Talarico C, Manelfi C, Cannalire R, Rossetti G, Gossen J, Albani S, Musiani F, Herzog K, Ye Y, Giabbai B, Demitri N, Jochmans D, Jonghe S, Rymenants J, Summa V, Tramontano E, Beccari AR, Leyssen P, Storici P, Neyts J, Gribbon P, Zaliani A. Kuzikov M, et al. Among authors: geisslinger g. ACS Pharmacol Transl Sci. 2021 Mar 11;4(3):1096-1110. doi: 10.1021/acsptsci.0c00216. eCollection 2021 Jun 11. ACS Pharmacol Transl Sci. 2021. PMID: 35287429 Free PMC article.
Functional genomics of pain in analgesic drug development and therapy.
Lötsch J, Doehring A, Mogil JS, Arndt T, Geisslinger G, Ultsch A. Lötsch J, et al. Among authors: geisslinger g. Pharmacol Ther. 2013 Jul;139(1):60-70. doi: 10.1016/j.pharmthera.2013.04.004. Epub 2013 Apr 6. Pharmacol Ther. 2013. PMID: 23567662 Review.
Drug Repurposing for the Development of Novel Analgesics.
Sisignano M, Parnham MJ, Geisslinger G. Sisignano M, et al. Among authors: geisslinger g. Trends Pharmacol Sci. 2016 Mar;37(3):172-183. doi: 10.1016/j.tips.2015.11.006. Epub 2015 Dec 17. Trends Pharmacol Sci. 2016. PMID: 26706620
598 results