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Medium-Chain Acyl-CoA Dehydrogenase Protects Mitochondria from Lipid Peroxidation in Glioblastoma.
Puca F, Yu F, Bartolacci C, Pettazzoni P, Carugo A, Huang-Hobbs E, Liu J, Zanca C, Carbone F, Del Poggetto E, Gumin J, Dasgupta P, Seth S, Srinivasan S, Lang FF, Sulman EP, Lorenzi PL, Tan L, Shan M, Tolstyka ZP, Kachman M, Zhang L, Gao S, Deem AK, Genovese G, Scaglioni PP, Lyssiotis CA, Viale A, Draetta GF. Puca F, et al. Among authors: scaglioni pp. Cancer Discov. 2021 Nov;11(11):2904-2923. doi: 10.1158/2159-8290.CD-20-1437. Epub 2021 May 26. Cancer Discov. 2021. PMID: 34039636 Free PMC article.
Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone.
Chakrabarti G, Moore ZR, Luo X, Ilcheva M, Ali A, Padanad M, Zhou Y, Xie Y, Burma S, Scaglioni PP, Cantley LC, DeBerardinis RJ, Kimmelman AC, Lyssiotis CA, Boothman DA. Chakrabarti G, et al. Among authors: scaglioni pp. Cancer Metab. 2015 Oct 12;3:12. doi: 10.1186/s40170-015-0137-1. eCollection 2015. Cancer Metab. 2015. PMID: 26462257 Free PMC article.
Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis.
Padanad MS, Konstantinidou G, Venkateswaran N, Melegari M, Rindhe S, Mitsche M, Yang C, Batten K, Huffman KE, Liu J, Tang X, Rodriguez-Canales J, Kalhor N, Shay JW, Minna JD, McDonald J, Wistuba II, DeBerardinis RJ, Scaglioni PP. Padanad MS, et al. Among authors: scaglioni pp. Cell Rep. 2016 Aug 9;16(6):1614-1628. doi: 10.1016/j.celrep.2016.07.009. Epub 2016 Jul 28. Cell Rep. 2016. PMID: 27477280 Free PMC article.
Ferroptosis: A Specific Vulnerability of RAS-Driven Cancers?
Andreani C, Bartolacci C, Scaglioni PP. Andreani C, et al. Among authors: scaglioni pp. Front Oncol. 2022 Jul 15;12:923915. doi: 10.3389/fonc.2022.923915. eCollection 2022. Front Oncol. 2022. PMID: 35912247 Free PMC article.
RHOA-FAK is a required signaling axis for the maintenance of KRAS-driven lung adenocarcinomas.
Konstantinidou G, Ramadori G, Torti F, Kangasniemi K, Ramirez RE, Cai Y, Behrens C, Dellinger MT, Brekken RA, Wistuba II, Heguy A, Teruya-Feldstein J, Scaglioni PP. Konstantinidou G, et al. Among authors: scaglioni pp. Cancer Discov. 2013 Apr;3(4):444-57. doi: 10.1158/2159-8290.CD-12-0388. Epub 2013 Jan 28. Cancer Discov. 2013. PMID: 23358651 Free PMC article.
Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer.
Bartolacci C, Andreani C, Vale G, Berto S, Melegari M, Crouch AC, Baluya DL, Kemble G, Hodges K, Starrett J, Politi K, Starnes SL, Lorenzini D, Raso MG, Solis Soto LM, Behrens C, Kadara H, Gao B, Wistuba II, Minna JD, McDonald JG, Scaglioni PP. Bartolacci C, et al. Among authors: scaglioni pp. Nat Commun. 2022 Jul 26;13(1):4327. doi: 10.1038/s41467-022-31963-4. Nat Commun. 2022. PMID: 35882862 Free PMC article.
Author Correction: Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer.
Bartolacci C, Andreani C, Vale G, Berto S, Melegari M, Crouch AC, Baluya DL, Kemble G, Hodges K, Starrett J, Politi K, Starnes SL, Lorenzini D, Raso MG, Solis Soto LM, Behrens C, Kadara H, Gao B, Wistuba II, Minna JD, McDonald JG, Scaglioni PP. Bartolacci C, et al. Among authors: scaglioni pp. Nat Commun. 2022 Aug 8;13(1):4640. doi: 10.1038/s41467-022-32459-x. Nat Commun. 2022. PMID: 35941179 Free PMC article. No abstract available.
Dual phosphoinositide 3-kinase/mammalian target of rapamycin blockade is an effective radiosensitizing strategy for the treatment of non-small cell lung cancer harboring K-RAS mutations.
Konstantinidou G, Bey EA, Rabellino A, Schuster K, Maira MS, Gazdar AF, Amici A, Boothman DA, Scaglioni PP. Konstantinidou G, et al. Among authors: scaglioni pp. Cancer Res. 2009 Oct 1;69(19):7644-52. doi: 10.1158/0008-5472.CAN-09-0823. Epub 2009 Sep 29. Cancer Res. 2009. PMID: 19789349 Free PMC article.
61 results