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Activation of protein kinase C-ζ in pancreatic β-cells in vivo improves glucose tolerance and induces β-cell expansion via mTOR activation.
Velazquez-Garcia S, Valle S, Rosa TC, Takane KK, Demirci C, Alvarez-Perez JC, Mellado-Gil JM, Ernst S, Scott DK, Vasavada RC, Alonso LC, Garcia-Ocaña A. Velazquez-Garcia S, et al. Among authors: alonso lc. Diabetes. 2011 Oct;60(10):2546-59. doi: 10.2337/db10-1783. Epub 2011 Sep 12. Diabetes. 2011. PMID: 21911744 Free PMC article.
ChREBP mediates glucose-stimulated pancreatic β-cell proliferation.
Metukuri MR, Zhang P, Basantani MK, Chin C, Stamateris RE, Alonso LC, Takane KK, Gramignoli R, Strom SC, O'Doherty RM, Stewart AF, Vasavada RC, Garcia-Ocaña A, Scott DK. Metukuri MR, et al. Among authors: alonso lc. Diabetes. 2012 Aug;61(8):2004-15. doi: 10.2337/db11-0802. Epub 2012 May 14. Diabetes. 2012. PMID: 22586588 Free PMC article.
Insulin demand regulates β cell number via the unfolded protein response.
Sharma RB, O'Donnell AC, Stamateris RE, Ha B, McCloskey KM, Reynolds PR, Arvan P, Alonso LC. Sharma RB, et al. Among authors: alonso lc. J Clin Invest. 2015 Oct 1;125(10):3831-46. doi: 10.1172/JCI79264. Epub 2015 Sep 21. J Clin Invest. 2015. PMID: 26389675 Free PMC article.
Islet biology, the CDKN2A/B locus and type 2 diabetes risk.
Kong Y, Sharma RB, Nwosu BU, Alonso LC. Kong Y, et al. Among authors: alonso lc. Diabetologia. 2016 Aug;59(8):1579-93. doi: 10.1007/s00125-016-3967-7. Epub 2016 May 7. Diabetologia. 2016. PMID: 27155872 Free PMC article. Review.
74 results