Dwight TA - Search Results

1

Remarkable and Unexpected Mechanism for (S)-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase.

Zhu W, Doubleday PF, Butrin A, Weerawarna PM, Melani RD, Catlin DS, Dwight TA, Liu D, Kelleher NL, Silverman RB. Zhu W, et al. Among authors: dwight ta. J Am Chem Soc. 2021 Jun 2;143(21):8193-8207. doi: 10.1021/jacs.1c03572. Epub 2021 May 20. J Am Chem Soc. 2021. PMID: 34014654 Free PMC article.

2

Synthesis and duplex-stabilizing properties of fluorinated N-methanocarbathymidine analogues locked in the C3'-endo conformation.

Jung ME, Dwight TA, Vigant F, Østergaard ME, Swayze EE, Seth PP. Jung ME, et al. Among authors: dwight ta. Angew Chem Int Ed Engl. 2014 Sep 8;53(37):9893-7. doi: 10.1002/anie.201405283. Epub 2014 Jul 15. Angew Chem Int Ed Engl. 2014. PMID: 25044699

3

Comparison of duplex stabilizing properties of 2'-fluorinated nucleic acid analogues with furanose and non-furanose sugar rings.

Østergaard ME, Dwight T, Berdeja A, Swayze EE, Jung ME, Seth PP. Østergaard ME, et al. J Org Chem. 2014 Sep 19;79(18):8877-81. doi: 10.1021/jo501381q. Epub 2014 Aug 27. J Org Chem. 2014. PMID: 25137618

4

Fluorinated Nucleotide Modifications Modulate Allele Selectivity of SNP-Targeting Antisense Oligonucleotides.

Østergaard ME, Nichols J, Dwight TA, Lima W, Jung ME, Swayze EE, Seth PP. Østergaard ME, et al. Among authors: dwight ta. Mol Ther Nucleic Acids. 2017 Jun 16;7:20-30. doi: 10.1016/j.omtn.2017.02.001. Epub 2017 Feb 9. Mol Ther Nucleic Acids. 2017. PMID: 28624195 Free PMC article.

5

Synthesis of 2-Ethenylcyclopropyl Aryl Ketones via Intramolecular S_N2-like Displacement of an Ester.

Jung ME, Sun DL, Dwight TA, Yu P, Li W, Houk KN. Jung ME, et al. Among authors: dwight ta. Org Lett. 2016 Oct 7;18(19):5138-5141. doi: 10.1021/acs.orglett.6b02588. Epub 2016 Sep 12. Org Lett. 2016. PMID: 27617843

6

Discovery of Brigatinib (AP26113), a Phosphine Oxide-Containing, Potent, Orally Active Inhibitor of Anaplastic Lymphoma Kinase.

Huang WS, Liu S, Zou D, Thomas M, Wang Y, Zhou T, Romero J, Kohlmann A, Li F, Qi J, Cai L, Dwight TA, Xu Y, Xu R, Dodd R, Toms A, Parillon L, Lu X, Anjum R, Zhang S, Wang F, Keats J, Wardwell SD, Ning Y, Xu Q, Moran LE, Mohemmad QK, Jang HG, Clackson T, Narasimhan NI, Rivera VM, Zhu X, Dalgarno D, Shakespeare WC. Huang WS, et al. Among authors: dwight ta. J Med Chem. 2016 May 26;59(10):4948-64. doi: 10.1021/acs.jmedchem.6b00306. Epub 2016 May 12. J Med Chem. 2016. PMID: 27144831

7

Oxidant-controlled regioselectivity in the oxidative arylation of N-acetylindoles.

Potavathri S, Dumas AS, Dwight TA, Naumiec GR, Hammann JM, Deboef B. Potavathri S, et al. Among authors: dwight ta. Tetrahedron Lett. 2008 Jun 16;49(25):4050-4053. doi: 10.1016/j.tetlet.2008.04.073. Tetrahedron Lett. 2008. PMID: 19652690 Free PMC article.

8

C-C bond formation via double C-H functionalization: aerobic oxidative coupling as a method for synthesizing heterocoupled biaryls.

Dwight TA, Rue NR, Charyk D, Josselyn R, DeBoef B. Dwight TA, et al. Org Lett. 2007 Aug 2;9(16):3137-9. doi: 10.1021/ol071308z. Epub 2007 Jul 7. Org Lett. 2007. PMID: 17616203 Free PMC article.

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