Dahal UP - Search Results

1

Mercapturate pathway metabolites of sotorasib, a covalent inhibitor of KRAS^G12C, are associated with renal toxicity in the Sprague Dawley rat.

Werner JA, Davies R, Wahlstrom J, Dahal UP, Jiang M, Stauber J, David B, Siska W, Thomas B, Ishida K, Humphreys WG, Lipford JR, Monticello TM. Werner JA, et al. Among authors: dahal up. Toxicol Appl Pharmacol. 2021 Jul 15;423:115578. doi: 10.1016/j.taap.2021.115578. Epub 2021 May 15. Toxicol Appl Pharmacol. 2021. PMID: 34004237

2

Absorption, Distribution, Metabolism, and Excretion of [¹⁴C]-Sotorasib in Rats and Dogs: Interspecies Differences in Absorption, Protein Conjugation and Metabolism.

Dahal UP, Rock BM, Rodgers J, Shen X, Wang Z, Wahlstrom JL. Dahal UP, et al. Drug Metab Dispos. 2022 May;50(5):600-612. doi: 10.1124/dmd.121.000798. Epub 2022 Feb 13. Drug Metab Dispos. 2022. PMID: 35153196

3

Absorption, metabolism and excretion of [¹⁴C]-sotorasib in healthy male subjects: characterization of metabolites and a minor albumin-sotorasib conjugate.

Vuu I, Dahal UP, Wang Z, Shen X, Rodgers J, Wahlstrom J, Houk B. Vuu I, et al. Among authors: dahal up. Cancer Chemother Pharmacol. 2022 Oct;90(4):357-367. doi: 10.1007/s00280-022-04470-y. Epub 2022 Sep 5. Cancer Chemother Pharmacol. 2022. PMID: 36063185

4

Strain-Dependent Variability of Early Discovery Small Molecule Pharmacokinetics in Mice: Does Strain Matter?

Barr JT, Tran TB, Rock BM, Wahlstrom JL, Dahal UP. Barr JT, et al. Among authors: dahal up. Drug Metab Dispos. 2020 Aug;48(8):613-621. doi: 10.1124/dmd.120.090621. Epub 2020 May 30. Drug Metab Dispos. 2020. PMID: 32474442

5

Benchmarking in vitro covalent binding burden as a tool to assess potential toxicity caused by nonspecific covalent binding of covalent drugs.

Dahal UP, Obach RS, Gilbert AM. Dahal UP, et al. Chem Res Toxicol. 2013 Nov 18;26(11):1739-45. doi: 10.1021/tx400301q. Epub 2013 Oct 28. Chem Res Toxicol. 2013. PMID: 24164572

6

Fraction Unbound for Liver Microsome and Hepatocyte Incubations for All Major Species Can Be Approximated Using a Single-Species Surrogate.

Barr JT, Lade JM, Tran TB, Dahal UP. Barr JT, et al. Among authors: dahal up. Drug Metab Dispos. 2019 Apr;47(4):419-423. doi: 10.1124/dmd.118.085936. Epub 2019 Feb 7. Drug Metab Dispos. 2019. PMID: 30733251

7

Chemical and computational methods for the characterization of covalent reactive groups for the prospective design of irreversible inhibitors.

Flanagan ME, Abramite JA, Anderson DP, Aulabaugh A, Dahal UP, Gilbert AM, Li C, Montgomery J, Oppenheimer SR, Ryder T, Schuff BP, Uccello DP, Walker GS, Wu Y, Brown MF, Chen JM, Hayward MM, Noe MC, Obach RS, Philippe L, Shanmugasundaram V, Shapiro MJ, Starr J, Stroh J, Che Y. Flanagan ME, et al. Among authors: dahal up. J Med Chem. 2014 Dec 11;57(23):10072-9. doi: 10.1021/jm501412a. Epub 2014 Nov 26. J Med Chem. 2014. PMID: 25375838

8

Small molecule quantification by liquid chromatography-mass spectrometry for metabolites of drugs and drug candidates.

Dahal UP, Jones JP, Davis JA, Rock DA. Dahal UP, et al. Drug Metab Dispos. 2011 Dec;39(12):2355-60. doi: 10.1124/dmd.111.040865. Epub 2011 Sep 21. Drug Metab Dispos. 2011. PMID: 21937735 Free PMC article.

9

The kinetic mechanism for cytochrome P450 metabolism of type II binding compounds: evidence supporting direct reduction.

Pearson J, Dahal UP, Rock D, Peng CC, Schenk JO, Joswig-Jones C, Jones JP. Pearson J, et al. Among authors: dahal up. Arch Biochem Biophys. 2011 Jul;511(1-2):69-79. doi: 10.1016/j.abb.2011.04.008. Epub 2011 Apr 21. Arch Biochem Biophys. 2011. PMID: 21530484 Free PMC article.

10

A tag-free collisionally induced fragmentation approach to detect drug-adducted proteins by mass spectrometry.

Ballard TE, Dahal UP, Bessire AJ, Schneider RP, Geoghegan KF, Vaz AD. Ballard TE, et al. Among authors: dahal up. Rapid Commun Mass Spectrom. 2015 Nov 30;29(22):2175-83. doi: 10.1002/rcm.7375. Rapid Commun Mass Spectrom. 2015. PMID: 26467230

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