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Identification of Novel Carbocyclic Pyrimidine Cyclic Dinucleotide STING Agonists for Antitumor Immunotherapy Using Systemic Intravenous Route.
J Med Chem. 2021 May 27;64(10):6902-6923. doi: 10.1021/acs.jmedchem.1c00374. Epub 2021 May 17.
J Med Chem. 2021.
PMID: 34000802
Free article.
Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome.
Xie SC, Metcalfe RD, Mizutani H, Puhalovich T, Hanssen E, Morton CJ, Du Y, Dogovski C, Huang SC, Ciavarri J, Hales P, Griffin RJ, Cohen LH, Chuang BC, Wittlin S, Deni I, Yeo T, Ward KE, Barry DC, Liu B, Gillett DL, Crespo-Fernandez BF, Ottilie S, Mittal N, Churchyard A, Ferguson D, Aguiar ACC, Guido RVC, Baum J, Hanson KK, Winzeler EA, Gamo FJ, Fidock DA, Baud D, Parker MW, Brand S, Dick LR, Griffin MDW, Gould AE, Tilley L.
Xie SC, et al. Among authors: ciavarri j.
Proc Natl Acad Sci U S A. 2021 Sep 28;118(39):e2107213118. doi: 10.1073/pnas.2107213118.
Proc Natl Acad Sci U S A. 2021.
PMID: 34548400
Free PMC article.
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A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment.
Hyer ML, Milhollen MA, Ciavarri J, Fleming P, Traore T, Sappal D, Huck J, Shi J, Gavin J, Brownell J, Yang Y, Stringer B, Griffin R, Bruzzese F, Soucy T, Duffy J, Rabino C, Riceberg J, Hoar K, Lublinsky A, Menon S, Sintchak M, Bump N, Pulukuri SM, Langston S, Tirrell S, Kuranda M, Veiby P, Newcomb J, Li P, Wu JT, Powe J, Dick LR, Greenspan P, Galvin K, Manfredi M, Claiborne C, Amidon BS, Bence NF.
Hyer ML, et al. Among authors: ciavarri j.
Nat Med. 2018 Feb;24(2):186-193. doi: 10.1038/nm.4474. Epub 2018 Jan 15.
Nat Med. 2018.
PMID: 29334375
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Potency switch between CHK1 and MK2: discovery of imidazo[1,2-a]pyrazine- and imidazo[1,2-c]pyrimidine-based kinase inhibitors.
Meng Z, Ciavarri JP, McRiner A, Zhao Y, Zhao L, Reddy PA, Zhang X, Fischmann TO, Whitehurst C, Arshad Siddiqui M.
Meng Z, et al. Among authors: ciavarri jp.
Bioorg Med Chem Lett. 2013 May 15;23(10):2863-7. doi: 10.1016/j.bmcl.2013.03.100. Epub 2013 Apr 4.
Bioorg Med Chem Lett. 2013.
PMID: 23587425
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A second-generation total synthesis of (+)-phorboxazole A.
Smith AB 3rd, Razler TM, Ciavarri JP, Hirose T, Ishikawa T, Meis RM.
Smith AB 3rd, et al. Among authors: ciavarri jp.
J Org Chem. 2008 Feb 15;73(4):1192-200. doi: 10.1021/jo7018152. Epub 2008 Jan 24.
J Org Chem. 2008.
PMID: 18215058
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(+)-Phorboxazole A synthetic studies. A highly convergent, second generation total synthesis of (+)-phorboxazole A.
Smith AB 3rd, Razler TM, Ciavarri JP, Hirose T, Ishikawa T.
Smith AB 3rd, et al. Among authors: ciavarri jp.
Org Lett. 2005 Sep 29;7(20):4399-402. doi: 10.1021/ol051584i.
Org Lett. 2005.
PMID: 16178543
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A divergent approach to the myriaporones and tedanolide: completion of the carbon skeleton of myriaporone 1.
Taylor RE, Hearn BR, Ciavarri JP.
Taylor RE, et al. Among authors: ciavarri jp.
Org Lett. 2002 Aug 22;4(17):2953-5. doi: 10.1021/ol026356s.
Org Lett. 2002.
PMID: 12182597
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