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Selective Janus kinase inhibition preserves interferon-λ-mediated antiviral responses.
Schnepf D, Crotta S, Thamamongood T, Stanifer M, Polcik L, Ohnemus A, Vier J, Jakob C, Llorian M, Gad HH, Hartmann R, Strobl B, Kirschnek S, Boulant S, Schwemmle M, Wack A, Staeheli P. Schnepf D, et al. Among authors: strobl b. Sci Immunol. 2021 May 14;6(59):eabd5318. doi: 10.1126/sciimmunol.abd5318. Sci Immunol. 2021. PMID: 33990378 Free PMC article.
Tyrosine kinase 2 controls IL-1ß production at the translational level.
Radwan M, Stiefvater R, Grunert T, Sharif O, Miller I, Marchetti-Deschmann M, Allmaier G, Gemeiner M, Knapp S, Kovarik P, Müller M, Strobl B. Radwan M, et al. Among authors: strobl b. J Immunol. 2010 Sep 15;185(6):3544-53. doi: 10.4049/jimmunol.0904000. Epub 2010 Aug 16. J Immunol. 2010. PMID: 20713887 Free PMC article.
TYK2 kinase activity is required for functional type I interferon responses in vivo.
Prchal-Murphy M, Semper C, Lassnig C, Wallner B, Gausterer C, Teppner-Klymiuk I, Kobolak J, Müller S, Kolbe T, Karaghiosoff M, Dinnyés A, Rülicke T, Leitner NR, Strobl B, Müller M. Prchal-Murphy M, et al. Among authors: strobl b. PLoS One. 2012;7(6):e39141. doi: 10.1371/journal.pone.0039141. Epub 2012 Jun 18. PLoS One. 2012. PMID: 22723949 Free PMC article.
STAT1β is not dominant negative and is capable of contributing to gamma interferon-dependent innate immunity.
Semper C, Leitner NR, Lassnig C, Parrini M, Mahlakõiv T, Rammerstorfer M, Lorenz K, Rigler D, Müller S, Kolbe T, Vogl C, Rülicke T, Staeheli P, Decker T, Müller M, Strobl B. Semper C, et al. Among authors: strobl b. Mol Cell Biol. 2014 Jun;34(12):2235-48. doi: 10.1128/MCB.00295-14. Epub 2014 Apr 7. Mol Cell Biol. 2014. PMID: 24710278 Free PMC article.
The antiviral response to gamma interferon.
Costa-Pereira AP, Williams TM, Strobl B, Watling D, Briscoe J, Kerr IM. Costa-Pereira AP, et al. Among authors: strobl b. J Virol. 2002 Sep;76(18):9060-8. doi: 10.1128/jvi.76.18.9060-9068.2002. J Virol. 2002. PMID: 12186889 Free PMC article.
126 results