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Upregulation of VCAM-1 in lymphatic collectors supports dendritic cell entry and rapid migration to lymph nodes in inflammation.
Arasa J, Collado-Diaz V, Kritikos I, Medina-Sanchez JD, Friess MC, Sigmund EC, Schineis P, Hunter MC, Tacconi C, Paterson N, Nagasawa T, Kiefer F, Makinen T, Detmar M, Moser M, Lämmermann T, Halin C. Arasa J, et al. Among authors: schineis p. J Exp Med. 2021 Jul 5;218(7):e20201413. doi: 10.1084/jem.20201413. Epub 2021 May 14. J Exp Med. 2021. PMID: 33988714 Free PMC article.
Cellular traffic through afferent lymphatic vessels.
Schineis P, Runge P, Halin C. Schineis P, et al. Vascul Pharmacol. 2019 Jan;112:31-41. doi: 10.1016/j.vph.2018.08.001. Epub 2018 Aug 7. Vascul Pharmacol. 2019. PMID: 30092362 Review.
Mechanosensitive ACKR4 scavenges CCR7 chemokines to facilitate T cell de-adhesion and passive transport by flow in inflamed afferent lymphatics.
Friess MC, Kritikos I, Schineis P, Medina-Sanchez JD, Gkountidi AO, Vallone A, Sigmund EC, Schwitter C, Vranova M, Matti C, Arasa J, Saygili Demir C, Bovay E, Proulx ST, Tomura M, Rot A, Legler DF, Petrova TV, Halin C. Friess MC, et al. Among authors: schineis p. Cell Rep. 2022 Feb 1;38(5):110334. doi: 10.1016/j.celrep.2022.110334. Cell Rep. 2022. PMID: 35108538 Free article.
ALCAM Mediates DC Migration Through Afferent Lymphatics and Promotes Allospecific Immune Reactions.
Willrodt AH, Salabarria AC, Schineis P, Ignatova D, Hunter MC, Vranova M, Golding-Ochsenbein AM, Sigmund E, Romagna A, Strassberger V, Fabbi M, Ferrini S, Cursiefen C, Neri D, Guenova E, Bock F, Halin C. Willrodt AH, et al. Among authors: schineis p. Front Immunol. 2019 Apr 12;10:759. doi: 10.3389/fimmu.2019.00759. eCollection 2019. Front Immunol. 2019. PMID: 31031759 Free PMC article.
Photochemical internalization (PCI)-mediated activation of CD8 T cells involves antigen uptake and CCR7-mediated transport by migratory dendritic cells to draining lymph nodes.
Schineis P, Kotkowska ZK, Vogel-Kindgen S, Friess MC, Theisen M, Schwyter D, Hausammann L, Subedi S, Varypataki EM, Waeckerle-Men Y, Kolm I, Kündig TM, Høgset A, Gander B, Halin C, Johansen P. Schineis P, et al. J Control Release. 2021 Apr 10;332:96-108. doi: 10.1016/j.jconrel.2021.02.014. Epub 2021 Feb 17. J Control Release. 2021. PMID: 33609623