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Page 1
Selective Requirement of MYB for Oncogenic Hyperactivation of a Translocated Enhancer in Leukemia.
Smeenk L, Ottema S, Mulet-Lazaro R, Ebert A, Havermans M, Varea AA, Fellner M, Pastoors D, van Herk S, Erpelinck-Verschueren C, Grob T, Hoogenboezem RM, Kavelaars FG, Matson DR, Bresnick EH, Bindels EM, Kentsis A, Zuber J, Delwel R. Smeenk L, et al. Cancer Discov. 2021 Nov;11(11):2868-2883. doi: 10.1158/2159-8290.CD-20-1793. Epub 2021 May 12. Cancer Discov. 2021. PMID: 33980539 Free PMC article.
Atypical 3q26/MECOM rearrangements genocopy inv(3)/t(3;3) in acute myeloid leukemia.
Ottema S, Mulet-Lazaro R, Beverloo HB, Erpelinck C, van Herk S, van der Helm R, Havermans M, Grob T, Valk PJM, Bindels E, Haferlach T, Haferlach C, Smeenk L, Delwel R. Ottema S, et al. Among authors: smeenk l. Blood. 2020 Jul 9;136(2):224-234. doi: 10.1182/blood.2019003701. Blood. 2020. PMID: 32219447 Free article.
Derepression of retroelements in acute myeloid leukemia with 3q aberrations.
Mika J, Ottema S, Kiehlmeier S, Kruse S, Smeenk L, Müller J, Schweiggert S, Herrmann C, Sanders M, Delwel R, Gröschel S. Mika J, et al. Among authors: smeenk l. Haematologica. 2021 Aug 1;106(8):2269-2273. doi: 10.3324/haematol.2020.277400. Haematologica. 2021. PMID: 33764001 Free PMC article. No abstract available.
The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops.
Ottema S, Mulet-Lazaro R, Erpelinck-Verschueren C, van Herk S, Havermans M, Arricibita Varea A, Vermeulen M, Beverloo HB, Gröschel S, Haferlach T, Haferlach C, J Wouters B, Bindels E, Smeenk L, Delwel R. Ottema S, et al. Among authors: smeenk l. Nat Commun. 2021 Sep 28;12(1):5679. doi: 10.1038/s41467-021-25862-3. Nat Commun. 2021. PMID: 34584081 Free PMC article.
EVI1 drives leukemogenesis through aberrant ERG activation.
Schmoellerl J, Barbosa IAM, Minnich M, Andersch F, Smeenk L, Havermans M, Eder T, Neumann T, Jude J, Fellner M, Ebert A, Steininger M, Delwel R, Grebien F, Zuber J. Schmoellerl J, et al. Among authors: smeenk l. Blood. 2023 Feb 2;141(5):453-466. doi: 10.1182/blood.2022016592. Blood. 2023. PMID: 36095844 Free article.
Oncogene EVI1 drives acute myeloid leukemia via a targetable interaction with CTBP2.
Pastoors D, Havermans M, Mulet-Lazaro R, Brian D, Noort W, Grasel J, Hoogenboezem R, Smeenk L, Demmers JAA, Milsom MD, Enver T, Groen RWJ, Bindels E, Delwel R. Pastoors D, et al. Among authors: smeenk l. Sci Adv. 2024 May 17;10(20):eadk9076. doi: 10.1126/sciadv.adk9076. Epub 2024 May 15. Sci Adv. 2024. PMID: 38748792 Free PMC article.
Genome-wide profiling of p63 DNA-binding sites identifies an element that regulates gene expression during limb development in the 7q21 SHFM1 locus.
Kouwenhoven EN, van Heeringen SJ, Tena JJ, Oti M, Dutilh BE, Alonso ME, de la Calle-Mustienes E, Smeenk L, Rinne T, Parsaulian L, Bolat E, Jurgelenaite R, Huynen MA, Hoischen A, Veltman JA, Brunner HG, Roscioli T, Oates E, Wilson M, Manzanares M, Gómez-Skarmeta JL, Stunnenberg HG, Lohrum M, van Bokhoven H, Zhou H. Kouwenhoven EN, et al. Among authors: smeenk l. PLoS Genet. 2010 Aug 19;6(8):e1001065. doi: 10.1371/journal.pgen.1001065. PLoS Genet. 2010. PMID: 20808887 Free PMC article.
30 results