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Selective degradation of CDK6 by a palbociclib based PROTAC.
Rana S, Bendjennat M, Kour S, King HM, Kizhake S, Zahid M, Natarajan A. Rana S, et al. Among authors: kizhake s. Bioorg Med Chem Lett. 2019 Jun 1;29(11):1375-1379. doi: 10.1016/j.bmcl.2019.03.035. Epub 2019 Mar 26. Bioorg Med Chem Lett. 2019. PMID: 30935795 Free PMC article.
Structure activity relationship (SAR) study identifies a quinoxaline urea analog that modulates IKKβ phosphorylation for pancreatic cancer therapy.
Sagar S, Singh S, Mallareddy JR, Sonawane YA, Napoleon JV, Rana S, Contreras JI, Rajesh C, Ezell EL, Kizhake S, Garrison JC, Radhakrishnan P, Natarajan A. Sagar S, et al. Among authors: kizhake s. Eur J Med Chem. 2021 Oct 15;222:113579. doi: 10.1016/j.ejmech.2021.113579. Epub 2021 May 30. Eur J Med Chem. 2021. PMID: 34098465 Free PMC article.
Symbiotic prodrugs (SymProDs) dual targeting of NFkappaB and CDK.
Rana S, Kour S, Sonawane YA, Robb CM, Contreras JI, Kizhake S, Zahid M, Karpf AR, Natarajan A. Rana S, et al. Among authors: kizhake s. Chem Biol Drug Des. 2020 Aug;96(2):773-784. doi: 10.1111/cbdd.13684. Epub 2020 Apr 22. Chem Biol Drug Des. 2020. PMID: 32237047 Free PMC article.
Aminopyrazole based CDK9 PROTAC sensitizes pancreatic cancer cells to venetoclax.
King HM, Rana S, Kubica SP, Mallareddy JR, Kizhake S, Ezell EL, Zahid M, Naldrett MJ, Alvarez S, Law HC, Woods NT, Natarajan A. King HM, et al. Among authors: kizhake s. Bioorg Med Chem Lett. 2021 Jul 1;43:128061. doi: 10.1016/j.bmcl.2021.128061. Epub 2021 Apr 23. Bioorg Med Chem Lett. 2021. PMID: 33895280 Free PMC article.
22 results