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Intrinsically disordered Meningioma-1 stabilizes the BAF complex to cause AML.
Riedel SS, Lu C, Xie HM, Nestler K, Vermunt MW, Lenard A, Bennett L, Speck NA, Hanamura I, Lessard JA, Blobel GA, Garcia BA, Bernt KM. Riedel SS, et al. Among authors: lenard a. Mol Cell. 2021 Jun 3;81(11):2332-2348.e9. doi: 10.1016/j.molcel.2021.04.014. Epub 2021 May 10. Mol Cell. 2021. PMID: 33974912 Free PMC article.
Menin is necessary for long term maintenance of meningioma-1 driven leukemia.
Libbrecht C, Xie HM, Kingsley MC, Haladyna JN, Riedel SS, Alikarami F, Lenard A, McGeehan GM, Ernst P, Bernt KM. Libbrecht C, et al. Among authors: lenard a. Leukemia. 2021 May;35(5):1405-1417. doi: 10.1038/s41375-021-01146-z. Epub 2021 Feb 4. Leukemia. 2021. PMID: 33542482 Free PMC article.
ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency.
Cao Z, Budinich KA, Huang H, Ren D, Lu B, Zhang Z, Chen Q, Zhou Y, Huang YH, Alikarami F, Kingsley MC, Lenard AK, Wakabayashi A, Khandros E, Bailis W, Qi J, Carroll MP, Blobel GA, Faryabi RB, Bernt KM, Berger SL, Shi J. Cao Z, et al. Among authors: lenard ak. Mol Cell. 2021 Sep 2;81(17):3604-3622.e10. doi: 10.1016/j.molcel.2021.07.018. Epub 2021 Aug 5. Mol Cell. 2021. PMID: 34358447 Free PMC article.
Epigenetic regulation of protein translation in KMT2A-rearranged AML.
Lenard A, Xie HM, Pastuer T, Shank T, Libbrecht C, Kingsley M, Riedel SS, Yuan ZF, Zhu N, Neff T, Bernt KM. Lenard A, et al. Exp Hematol. 2020 May;85:57-69. doi: 10.1016/j.exphem.2020.04.007. Epub 2020 May 11. Exp Hematol. 2020. PMID: 32437908 Free PMC article.
Effect of Clarithromycin, a Strong CYP3A and P-glycoprotein Inhibitor, on the Pharmacokinetics of Edoxaban in Healthy Volunteers and the Evaluation of the Drug Interaction with Other Oral Factor Xa Inhibitors by a Microdose Cocktail Approach.
Lenard A, Hermann SA, Stoll F, Burhenne J, Foerster KI, Mikus G, Meid AD, Haefeli WE, Blank A. Lenard A, et al. Cardiovasc Drugs Ther. 2023 Mar 4. doi: 10.1007/s10557-023-07443-2. Online ahead of print. Cardiovasc Drugs Ther. 2023. PMID: 36870039
33 results