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Gold(I) Phosphine Derivatives with Improved Selectivity as Topically Active Drug Leads to Overcome 5-Nitroheterocyclic Drug Resistance in Trichomonas vaginalis.
Miyamoto Y, Aggarwal S, Celaje JJA, Ihara S, Ang J, Eremin DB, Land KM, Wrischnik LA, Zhang L, Fokin VV, Eckmann L. Miyamoto Y, et al. Among authors: fokin vv. J Med Chem. 2021 May 27;64(10):6608-6620. doi: 10.1021/acs.jmedchem.0c01926. Epub 2021 May 11. J Med Chem. 2021. PMID: 33974434 Free PMC article.
Synthesis and electrochemistry of 2-ethenyl and 2-ethanyl derivatives of 5-nitroimidazole and antimicrobial activity against Giardia lamblia.
Valdez CA, Tripp JC, Miyamoto Y, Kalisiak J, Hruz P, Andersen YS, Brown SE, Kangas K, Arzu LV, Davids BJ, Gillin FD, Upcroft JA, Upcroft P, Fokin VV, Smith DK, Sharpless KB, Eckmann L. Valdez CA, et al. Among authors: fokin vv. J Med Chem. 2009 Jul 9;52(13):4038-53. doi: 10.1021/jm900356n. J Med Chem. 2009. PMID: 19480409 Free PMC article.
Expanded therapeutic potential in activity space of next-generation 5-nitroimidazole antimicrobials with broad structural diversity.
Miyamoto Y, Kalisiak J, Korthals K, Lauwaet T, Cheung DY, Lozano R, Cobo ER, Upcroft P, Upcroft JA, Berg DE, Gillin FD, Fokin VV, Sharpless KB, Eckmann L. Miyamoto Y, et al. Among authors: fokin vv. Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17564-9. doi: 10.1073/pnas.1302664110. Epub 2013 Oct 7. Proc Natl Acad Sci U S A. 2013. PMID: 24101497 Free PMC article.
Click Chemistry-Facilitated Structural Diversification of Nitrothiazoles, Nitrofurans, and Nitropyrroles Enhances Antimicrobial Activity against Giardia lamblia.
Kim WJ, Korthals KA, Li S, Le C, Kalisiak J, Sharpless KB, Fokin VV, Miyamoto Y, Eckmann L. Kim WJ, et al. Among authors: fokin vv. Antimicrob Agents Chemother. 2017 May 24;61(6):e02397-16. doi: 10.1128/AAC.02397-16. Print 2017 Jun. Antimicrob Agents Chemother. 2017. PMID: 28396548 Free PMC article.
Click chemistry-facilitated comprehensive identification of proteins adducted by antimicrobial 5-nitroimidazoles for discovery of alternative drug targets against giardiasis.
Lauwaet T, Miyamoto Y, Ihara S, Le C, Kalisiak J, Korthals KA, Ghassemian M, Smith DK, Sharpless KB, Fokin VV, Eckmann L. Lauwaet T, et al. Among authors: fokin vv. PLoS Negl Trop Dis. 2020 Apr 17;14(4):e0008224. doi: 10.1371/journal.pntd.0008224. eCollection 2020 Apr. PLoS Negl Trop Dis. 2020. PMID: 32302296 Free PMC article.
111 results