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Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance.
Rode B, Shi J, Endesh N, Drinkhill MJ, Webster PJ, Lotteau SJ, Bailey MA, Yuldasheva NY, Ludlow MJ, Cubbon RM, Li J, Futers TS, Morley L, Gaunt HJ, Marszalek K, Viswambharan H, Cuthbertson K, Baxter PD, Foster R, Sukumar P, Weightman A, Calaghan SC, Wheatcroft SB, Kearney MT, Beech DJ. Rode B, et al. Among authors: viswambharan h. Nat Commun. 2017 Aug 24;8(1):350. doi: 10.1038/s41467-017-00429-3. Nat Commun. 2017. PMID: 28839146 Free PMC article.
Novel Paracrine Action of Endothelium Enhances Glucose Uptake in Muscle and Fat.
Viswambharan H, Yuldasheva NY, Imrie H, Bridge K, Haywood NJ, Skromna A, Hemmings KE, Clark ER, Gatenby VK, Cordell P, Simmons KJ, Makava N, Abudushalamu Y, Endesh N, Brown J, Walker AMN, Futers ST, Porter KE, Cubbon RM, Naseem K, Shah AM, Beech DJ, Wheatcroft SB, Kearney MT, Sukumar P. Viswambharan H, et al. Circ Res. 2021 Sep 17;129(7):720-734. doi: 10.1161/CIRCRESAHA.121.319517. Epub 2021 Aug 21. Circ Res. 2021. PMID: 34420367 Free PMC article.
Endothelium-specific insulin resistance leads to accelerated atherosclerosis in areas with disturbed flow patterns: a role for reactive oxygen species.
Gage MC, Yuldasheva NY, Viswambharan H, Sukumar P, Cubbon RM, Galloway S, Imrie H, Skromna A, Smith J, Jackson CL, Kearney MT, Wheatcroft SB. Gage MC, et al. Among authors: viswambharan h. Atherosclerosis. 2013 Sep;230(1):131-9. doi: 10.1016/j.atherosclerosis.2013.06.017. Epub 2013 Jun 29. Atherosclerosis. 2013. PMID: 23958265
Piezo1 channel activation mimics high glucose as a stimulator of insulin release.
Deivasikamani V, Dhayalan S, Abudushalamu Y, Mughal R, Visnagri A, Cuthbertson K, Scragg JL, Munsey TS, Viswambharan H, Muraki K, Foster R, Sivaprasadarao A, Kearney MT, Beech DJ, Sukumar P. Deivasikamani V, et al. Among authors: viswambharan h. Sci Rep. 2019 Nov 14;9(1):16876. doi: 10.1038/s41598-019-51518-w. Sci Rep. 2019. PMID: 31727906 Free PMC article.
Nox2 NADPH oxidase has a critical role in insulin resistance-related endothelial cell dysfunction.
Sukumar P, Viswambharan H, Imrie H, Cubbon RM, Yuldasheva N, Gage M, Galloway S, Skromna A, Kandavelu P, Santos CX, Gatenby VK, Smith J, Beech DJ, Wheatcroft SB, Channon KM, Shah AM, Kearney MT. Sukumar P, et al. Among authors: viswambharan h. Diabetes. 2013 Jun;62(6):2130-4. doi: 10.2337/db12-1294. Epub 2013 Jan 24. Diabetes. 2013. PMID: 23349484 Free PMC article.
Vascular insulin-like growth factor-I resistance and diet-induced obesity.
Imrie H, Abbas A, Viswambharan H, Rajwani A, Cubbon RM, Gage M, Kahn M, Ezzat VA, Duncan ER, Grant PJ, Ajjan R, Wheatcroft SB, Kearney MT. Imrie H, et al. Among authors: viswambharan h. Endocrinology. 2009 Oct;150(10):4575-82. doi: 10.1210/en.2008-1641. Epub 2009 Jul 16. Endocrinology. 2009. PMID: 19608653
36 results