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Proopiomelanocortin Deficiency Treated with a Melanocortin-4 Receptor Agonist.
Kühnen P, Clément K, Wiegand S, Blankenstein O, Gottesdiener K, Martini LL, Mai K, Blume-Peytavi U, Grüters A, Krude H. Kühnen P, et al. Among authors: wiegand s. N Engl J Med. 2016 Jul 21;375(3):240-6. doi: 10.1056/NEJMoa1512693. N Engl J Med. 2016. PMID: 27468060 Free article. Clinical Trial.
Interindividual Variation in DNA Methylation at a Putative POMC Metastable Epiallele Is Associated with Obesity.
Kühnen P, Handke D, Waterland RA, Hennig BJ, Silver M, Fulford AJ, Dominguez-Salas P, Moore SE, Prentice AM, Spranger J, Hinney A, Hebebrand J, Heppner FL, Walzer L, Grötzinger C, Gromoll J, Wiegand S, Grüters A, Krude H. Kühnen P, et al. Among authors: wiegand s. Cell Metab. 2016 Sep 13;24(3):502-509. doi: 10.1016/j.cmet.2016.08.001. Epub 2016 Aug 25. Cell Metab. 2016. PMID: 27568547 Free article.
Investigation of Naturally Occurring Single-Nucleotide Variants in Human TAAR1.
Mühlhaus J, Dinter J, Jyrch S, Teumer A, Jacobi SF, Homuth G, Kühnen P, Wiegand S, Grüters A, Völzke H, Raile K, Kleinau G, Krude H, Biebermann H. Mühlhaus J, et al. Among authors: wiegand s. Front Pharmacol. 2017 Nov 24;8:807. doi: 10.3389/fphar.2017.00807. eCollection 2017. Front Pharmacol. 2017. PMID: 29225575 Free PMC article.
MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency.
Clément K, Biebermann H, Farooqi IS, Van der Ploeg L, Wolters B, Poitou C, Puder L, Fiedorek F, Gottesdiener K, Kleinau G, Heyder N, Scheerer P, Blume-Peytavi U, Jahnke I, Sharma S, Mokrosinski J, Wiegand S, Müller A, Weiß K, Mai K, Spranger J, Grüters A, Blankenstein O, Krude H, Kühnen P. Clément K, et al. Among authors: wiegand s. Nat Med. 2018 May;24(5):551-555. doi: 10.1038/s41591-018-0015-9. Epub 2018 May 7. Nat Med. 2018. PMID: 29736023 Clinical Trial.
Tissue Sodium Content and Arterial Hypertension in Obese Adolescents.
Roth S, Markó L, Birukov A, Hennemuth A, Kühnen P, Jones A, Ghorbani N, Linz P, Müller DN, Wiegand S, Berger F, Kuehne T, Kelm M. Roth S, et al. Among authors: wiegand s. J Clin Med. 2019 Nov 21;8(12):2036. doi: 10.3390/jcm8122036. J Clin Med. 2019. PMID: 31766426 Free PMC article.
650 results