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Discovery and Characterization of VU0529331, a Synthetic Small-Molecule Activator of Homomeric G Protein-Gated, Inwardly Rectifying, Potassium (GIRK) Channels.
Kozek KA, Du Y, Sharma S, Prael FJ 3rd, Spitznagel BD, Kharade SV, Denton JS, Hopkins CR, Weaver CD. Kozek KA, et al. Among authors: sharma s. ACS Chem Neurosci. 2019 Jan 16;10(1):358-370. doi: 10.1021/acschemneuro.8b00287. Epub 2018 Sep 13. ACS Chem Neurosci. 2019. PMID: 30136838 Free PMC article.
Discovery, synthesis and biological characterization of a series of N-(1-(1,1-dioxidotetrahydrothiophen-3-yl)-3-methyl-1H-pyrazol-5-yl)acetamide ethers as novel GIRK1/2 potassium channel activators.
Sharma S, Lesiak L, Aretz CD, Du Y, Kumar S, Gautam N, Alnouti Y, Dhuria NV, Chhonker YS, Weaver CD, Hopkins CR. Sharma S, et al. RSC Med Chem. 2021 Jun 21;12(8):1366-1373. doi: 10.1039/d1md00129a. eCollection 2021 Aug 18. RSC Med Chem. 2021. PMID: 34458739 Free PMC article.
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