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Pharmacokinetics of protein and peptide conjugates.
Bumbaca B, Li Z, Shah DK. Bumbaca B, et al. Among authors: li z. Drug Metab Pharmacokinet. 2019 Feb;34(1):42-54. doi: 10.1016/j.dmpk.2018.11.001. Epub 2018 Nov 22. Drug Metab Pharmacokinet. 2019. PMID: 30573392 Free PMC article. Review.
Effect of Size on Solid Tumor Disposition of Protein Therapeutics.
Li Z, Li Y, Chang HP, Chang HY, Guo L, Shah DK. Li Z, et al. Among authors: li y. Drug Metab Dispos. 2019 Oct;47(10):1136-1145. doi: 10.1124/dmd.119.087809. Epub 2019 Aug 6. Drug Metab Dispos. 2019. PMID: 31387870 Free PMC article.
Two-pore physiologically based pharmacokinetic model validation using whole-body biodistribution of trastuzumab and different-size fragments in mice.
Li Z, Li Y, Chang HP, Yu X, Shah DK. Li Z, et al. Among authors: li y. J Pharmacokinet Pharmacodyn. 2021 Oct;48(5):743-762. doi: 10.1007/s10928-021-09772-x. Epub 2021 Jun 19. J Pharmacokinet Pharmacodyn. 2021. PMID: 34146191
In the past, our lab proposed a two-pore PBPK model for different-size protein therapeutics using de novo derived parameters and the model was validated using plasma PK data of different-size antibody fragments digitized from the literature (Li Z, Shah DK, J Pharmac …
In the past, our lab proposed a two-pore PBPK model for different-size protein therapeutics using de novo derived parameters and the model w …
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