Two-pore physiologically based pharmacokinetic model validation using whole-body biodistribution of trastuzumab and different-size fragments in mice.
Li Z, Li Y, Chang HP, Yu X, Shah DK.
Li Z, et al. Among authors: li y.
J Pharmacokinet Pharmacodyn. 2021 Oct;48(5):743-762. doi: 10.1007/s10928-021-09772-x. Epub 2021 Jun 19.
J Pharmacokinet Pharmacodyn. 2021.
PMID: 34146191
In the past, our lab proposed a two-pore PBPK model for different-size protein therapeutics using de novo derived parameters and the model was validated using plasma PK data of different-size antibody fragments digitized from the literature (Li Z, Shah DK, J Pharmac …
In the past, our lab proposed a two-pore PBPK model for different-size protein therapeutics using de novo derived parameters and the model w …