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Improving Right Ventricular Function by Increasing BMP Signaling with FK506.
Boehm M, Tian X, Ali MK, Mao Y, Ichimura K, Zhao M, Kuramoto K, Dannewitz Prosseda S, Fajardo G, Dufva MJ, Qin X, Kheyfets VO, Bernstein D, Reddy S, Metzger RJ, Zamanian RT, Haddad F, Spiekerkoetter E. Boehm M, et al. Among authors: spiekerkoetter e. Am J Respir Cell Mol Biol. 2021 Sep;65(3):272-287. doi: 10.1165/rcmb.2020-0528OC. Am J Respir Cell Mol Biol. 2021. PMID: 33938785 Free PMC article.
Increased fibulin-5 and elastin in S100A4/Mts1 mice with pulmonary hypertension.
Merklinger SL, Wagner RA, Spiekerkoetter E, Hinek A, Knutsen RH, Kabir MG, Desai K, Hacker S, Wang L, Cann GM, Ambartsumian NS, Lukanidin E, Bernstein D, Husain M, Mecham RP, Starcher B, Yanagisawa H, Rabinovitch M. Merklinger SL, et al. Among authors: spiekerkoetter e. Circ Res. 2005 Sep 16;97(6):596-604. doi: 10.1161/01.RES.0000182425.49768.8a. Epub 2005 Aug 18. Circ Res. 2005. PMID: 16109920
Loss of adenomatous poliposis coli-α3 integrin interaction promotes endothelial apoptosis in mice and humans.
de Jesus Perez VA, Yuan K, Orcholski ME, Sawada H, Zhao M, Li CG, Tojais NF, Nickel N, Rajagopalan V, Spiekerkoetter E, Wang L, Dutta R, Bernstein D, Rabinovitch M. de Jesus Perez VA, et al. Among authors: spiekerkoetter e. Circ Res. 2012 Dec 7;111(12):1551-64. doi: 10.1161/CIRCRESAHA.112.267849. Epub 2012 Sep 25. Circ Res. 2012. PMID: 23011394 Free PMC article.
FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension.
Spiekerkoetter E, Tian X, Cai J, Hopper RK, Sudheendra D, Li CG, El-Bizri N, Sawada H, Haghighat R, Chan R, Haghighat L, de Jesus Perez V, Wang L, Reddy S, Zhao M, Bernstein D, Solow-Cordero DE, Beachy PA, Wandless TJ, Ten Dijke P, Rabinovitch M. Spiekerkoetter E, et al. J Clin Invest. 2013 Aug;123(8):3600-13. doi: 10.1172/JCI65592. Epub 2013 Jul 15. J Clin Invest. 2013. PMID: 23867624 Free PMC article.
Current clinical management of pulmonary arterial hypertension.
Zamanian RT, Kudelko KT, Sung YK, Perez VJ, Liu J, Spiekerkoetter E. Zamanian RT, et al. Among authors: spiekerkoetter e. Circ Res. 2014 Jun 20;115(1):131-147. doi: 10.1161/CIRCRESAHA.115.303827. Circ Res. 2014. PMID: 24951763 Free PMC article. Review.
Elafin Reverses Pulmonary Hypertension via Caveolin-1-Dependent Bone Morphogenetic Protein Signaling.
Nickel NP, Spiekerkoetter E, Gu M, Li CG, Li H, Kaschwich M, Diebold I, Hennigs JK, Kim KY, Miyagawa K, Wang L, Cao A, Sa S, Jiang X, Stockstill RW, Nicolls MR, Zamanian RT, Bland RD, Rabinovitch M. Nickel NP, et al. Among authors: spiekerkoetter e. Am J Respir Crit Care Med. 2015 Jun 1;191(11):1273-86. doi: 10.1164/rccm.201412-2291OC. Am J Respir Crit Care Med. 2015. PMID: 25853696 Free PMC article.
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