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Phase 1 clinical trial of losmapimod in facioscapulohumeral dystrophy: Safety, tolerability, pharmacokinetics, and target engagement.
Mellion ML, Ronco L, Berends CL, Pagan L, Brooks S, van Esdonk MJ, van Brummelen EMJ, Odueyungbo A, Thompson LA, Hage M, Badrising UA, Raines S, Tracewell WG, van Engelen B, Cadavid D, Groeneveld GJ. Mellion ML, et al. Among authors: groeneveld gj. Br J Clin Pharmacol. 2021 Dec;87(12):4658-4669. doi: 10.1111/bcp.14884. Epub 2021 May 14. Br J Clin Pharmacol. 2021. PMID: 33931884 Free article. Clinical Trial.
Pharmacokinetics and pharmacodynamics of multiple doses of BG00010, a neurotrophic factor with anti-hyperalgesic effects, in patients with sciatica.
Okkerse P, Hay JL, Versage E, Tang Y, Galluppi G, Ravina B, Verma A, Williams L, Aycardi E, Groeneveld GJ. Okkerse P, et al. Among authors: groeneveld gj. Br J Clin Pharmacol. 2016 Jul;82(1):108-17. doi: 10.1111/bcp.12941. Epub 2016 May 13. Br J Clin Pharmacol. 2016. PMID: 27016000 Free PMC article. Clinical Trial.
An anti-nicotinic cognitive challenge model using mecamylamine in comparison with the anti-muscarinic cognitive challenge using scopolamine.
Baakman AC, Alvarez-Jimenez R, Rissmann R, Klaassen ES, Stevens J, Goulooze SC, den Burger JCG, Swart EL, van Gerven JMA, Groeneveld GJ. Baakman AC, et al. Among authors: groeneveld gj. Br J Clin Pharmacol. 2017 Aug;83(8):1676-1687. doi: 10.1111/bcp.13268. Epub 2017 Apr 8. Br J Clin Pharmacol. 2017. PMID: 28217868 Free PMC article. Clinical Trial.
Validation of a pharmacological model for mitochondrial dysfunction in healthy subjects using simvastatin: A randomized placebo-controlled proof-of-pharmacology study.
van Diemen MPJ, Berends CL, Akram N, Wezel J, Teeuwisse WM, Mik BG, Kan HE, Webb A, Beenakker JWM, Groeneveld GJ. van Diemen MPJ, et al. Among authors: groeneveld gj. Eur J Pharmacol. 2017 Nov 15;815:290-297. doi: 10.1016/j.ejphar.2017.09.031. Epub 2017 Sep 21. Eur J Pharmacol. 2017. PMID: 28943100 Clinical Trial.
142 results