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Closed-loop trans-skull ultrasound hyperthermia leads to improved drug delivery from thermosensitive drugs and promotes changes in vascular transport dynamics in brain tumors.
Kim C, Guo Y, Velalopoulou A, Leisen J, Motamarry A, Ramajayam K, Aryal M, Haemmerich D, Arvanitis CD. Kim C, et al. Among authors: velalopoulou a. Theranostics. 2021 May 24;11(15):7276-7293. doi: 10.7150/thno.54630. eCollection 2021. Theranostics. 2021. PMID: 34158850 Free PMC article.
Intercellular pathways of cancer treatment-related cardiotoxicity and their therapeutic implications: The paradigm of radiotherapy.
Logotheti S, Pavlopoulou A, Rudsari HK, Galow AM, Kafali Y, Kyrodimos E, Giotakis AI, Marquardt S, Velalopoulou A, Verginadis II, Koumenis C, Stiewe T, Zoidakis J, Balasingham I, David R, Georgakilas AG. Logotheti S, et al. Among authors: velalopoulou a. Pharmacol Ther. 2024 May 30:108670. doi: 10.1016/j.pharmthera.2024.108670. Online ahead of print. Pharmacol Ther. 2024. PMID: 38823489 Review.
Proton FLASH Radiotherapy Ameliorates Radiation-induced Salivary Gland Dysfunction and Oral Mucositis and Increases Survival in a Mouse Model of Head and Neck Cancer.
Chowdhury P, Velalopoulou A, Verginadis II, Morcos G, Loo PE, Kim MM, Motlagh SAO, Shoniyozov K, Diffenderfer ES, Ocampo EA, Putt M, Assenmacher CA, Radaelli E, Lu J, Qin L, Liu H, Leli NM, Girdhani S, Denef N, Vander Stappen F, Cengel KA, Busch TM, Metz JM, Dong L, Lin A, Koumenis C. Chowdhury P, et al. Among authors: velalopoulou a. Mol Cancer Ther. 2024 Jun 4;23(6):877-889. doi: 10.1158/1535-7163.MCT-23-0663. Mol Cancer Ther. 2024. PMID: 38593239
A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression.
Verginadis II, Avgousti H, Monslow J, Skoufos G, Chinga F, Kim K, Leli NM, Karagounis IV, Bell BI, Velalopoulou A, Salinas CS, Wu VS, Li Y, Ye J, Scott DA, Osterman AL, Sengupta A, Weljie A, Huang M, Zhang D, Fan Y, Radaelli E, Tobias JW, Rambow F, Karras P, Marine JC, Xu X, Hatzigeorgiou AG, Ryeom S, Diehl JA, Fuchs SY, Puré E, Koumenis C. Verginadis II, et al. Among authors: velalopoulou a. Nat Cell Biol. 2022 Jun;24(6):940-953. doi: 10.1038/s41556-022-00918-8. Epub 2022 Jun 2. Nat Cell Biol. 2022. PMID: 35654839 Free PMC article.
Ultrafast Tracking of Oxygen Dynamics During Proton FLASH.
El Khatib M, Van Slyke AL, Velalopoulou A, Kim MM, Shoniyozov K, Allu SR, Diffenderfer EE, Busch TM, Wiersma RD, Koch CJ, Vinogradov SA. El Khatib M, et al. Among authors: velalopoulou a. Int J Radiat Oncol Biol Phys. 2022 Jul 1;113(3):624-634. doi: 10.1016/j.ijrobp.2022.03.016. Epub 2022 Mar 18. Int J Radiat Oncol Biol Phys. 2022. PMID: 35314293 Free PMC article.
FLASH Proton Radiotherapy Spares Normal Epithelial and Mesenchymal Tissues While Preserving Sarcoma Response.
Velalopoulou A, Karagounis IV, Cramer GM, Kim MM, Skoufos G, Goia D, Hagan S, Verginadis II, Shoniyozov K, Chiango J, Cerullo M, Varner K, Yao L, Qin L, Hatzigeorgiou AG, Minn AJ, Putt M, Lanza M, Assenmacher CA, Radaelli E, Huck J, Diffenderfer E, Dong L, Metz J, Koumenis C, Cengel KA, Maity A, Busch TM. Velalopoulou A, et al. Cancer Res. 2021 Sep 15;81(18):4808-4821. doi: 10.1158/0008-5472.CAN-21-1500. Epub 2021 Jul 28. Cancer Res. 2021. PMID: 34321243 Free PMC article.
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