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Development of ProTx-II Analogues as Highly Selective Peptide Blockers of Nav1.7 for the Treatment of Pain.
Adams GL, Pall PS, Grauer SM, Zhou X, Ballard JE, Vavrek M, Kraus RL, Morissette P, Li N, Colarusso S, Bianchi E, Palani A, Klein R, John CT, Wang D, Tudor M, Nolting AF, Biba M, Nowak T, Makarov AA, Reibarkh M, Buevich AV, Zhong W, Regalado EL, Wang X, Gao Q, Shahripour A, Zhu Y, de Simone D, Frattarelli T, Pasquini NM, Magotti P, Iaccarino R, Li Y, Solly K, Lee KJ, Wang W, Chen F, Zeng H, Wang J, Regan H, Amin RP, Regan CP, Burgey CS, Henze DA, Sun C, Tellers DM. Adams GL, et al. Among authors: makarov aa. J Med Chem. 2022 Jan 13;65(1):485-496. doi: 10.1021/acs.jmedchem.1c01570. Epub 2021 Dec 21. J Med Chem. 2022. PMID: 34931831
A chemoenzymatic strategy for site-selective functionalization of native peptides and proteins.
Fryszkowska A, An C, Alvizo O, Banerjee G, Canada KA, Cao Y, DeMong D, Devine PN, Duan D, Elgart DM, Farasat I, Gauthier DR, Guidry EN, Jia X, Kong J, Kruse N, Lexa KW, Makarov AA, Mann BF, Milczek EM, Mitchell V, Nazor J, Neri C, Orr RK, Orth P, Phillips EM, Riggins JN, Schafer WA, Silverman SM, Strulson CA, Subramanian N, Voladri R, Yang H, Yang J, Yi X, Zhang X, Zhong W. Fryszkowska A, et al. Among authors: makarov aa. Science. 2022 Jun 17;376(6599):1321-1327. doi: 10.1126/science.abn2009. Epub 2022 Jun 16. Science. 2022. PMID: 35709255
Chaotropic Effects in Sub/Supercritical Fluid Chromatography via Ammonium Hydroxide in Water-Rich Modifiers: Enabling Separation of Peptides and Highly Polar Pharmaceuticals at the Preparative Scale.
Liu J, Makarov AA, Bennett R, Haidar Ahmad IA, DaSilva J, Reibarkh M, Mangion I, Mann BF, Regalado EL. Liu J, et al. Among authors: makarov aa. Anal Chem. 2019 Nov 5;91(21):13907-13915. doi: 10.1021/acs.analchem.9b03408. Epub 2019 Oct 8. Anal Chem. 2019. PMID: 31549812
Comprehensive online multicolumn two-dimensional liquid chromatography-diode array detection-mass spectrometry workflow as a framework for chromatographic screening and analysis of new drug substances.
Pickens CJ, Haidar Ahmad IA, Makarov AA, Bennett R, Mann BF, Regalado EL. Pickens CJ, et al. Among authors: makarov aa. Anal Bioanal Chem. 2020 Apr;412(11):2655-2663. doi: 10.1007/s00216-020-02498-8. Epub 2020 Mar 4. Anal Bioanal Chem. 2020. PMID: 32128644
361 results