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The Impact of Dextran Sodium Sulfate-Induced Gastrointestinal Injury on the Pharmacokinetic Parameters of Donepezil and Its Active Metabolite 6-O-desmethyldonepezil, and Gastric Myoelectric Activity in Experimental Pigs.
Bures J, Tacheci I, Kvetina J, Radochova V, Prchal L, Kohoutova D, Valis M, Novak M, Dolezal R, Kopacova M, Rejchrt S, Sestak V, Knoblochova V, Peterova E, Zdarova Karasova J. Bures J, et al. Among authors: prchal l. Molecules. 2021 Apr 9;26(8):2160. doi: 10.3390/molecules26082160. Molecules. 2021. PMID: 33918638 Free PMC article.
Substituted Piperazines as Novel Potential Radioprotective Agents.
Filipova A, Marek J, Havelek R, Pejchal J, Jelicova M, Cizkova J, Majorosova M, Muckova L, Kucera T, Prchal L, Psotka M, Zivna N, Koutova D, Sinkorova Z, Rezacova M, Tichy A. Filipova A, et al. Among authors: prchal l. Molecules. 2020 Jan 25;25(3):532. doi: 10.3390/molecules25030532. Molecules. 2020. PMID: 31991816 Free PMC article.
Benzothiazolyl Ureas are Low Micromolar and Uncompetitive Inhibitors of 17β-HSD10 with Implications to Alzheimer's Disease Treatment.
Schmidt M, Benek O, Vinklarova L, Hrabinova M, Zemanova L, Chribek M, Kralova V, Hroch L, Dolezal R, Lycka A, Prchal L, Jun D, Aitken L, Gunn-Moore F, Kuca K, Musilek K. Schmidt M, et al. Among authors: prchal l. Int J Mol Sci. 2020 Mar 17;21(6):2059. doi: 10.3390/ijms21062059. Int J Mol Sci. 2020. PMID: 32192199 Free PMC article.
Wide-Antimicrobial Spectrum of Picolinium Salts.
Salajkova S, Benkova M, Marek J, Sleha R, Prchal L, Malinak D, Dolezal R, Sepčić K, Gunde-Cimerman N, Kuca K, Soukup O. Salajkova S, et al. Among authors: prchal l. Molecules. 2020 May 11;25(9):2254. doi: 10.3390/molecules25092254. Molecules. 2020. PMID: 32403238 Free PMC article.
The wide-spectrum antimicrobial effect of novel N-alkyl monoquaternary ammonium salts and their mixtures; the QSAR study against bacteria.
Soukup O, Benkova M, Dolezal R, Sleha R, Malinak D, Salajkova S, Markova A, Hympanova M, Prchal L, Ryskova L, Hobzova L, Sepčić K, Gunde-Cimerman N, Korabecny J, Jun D, Bostikova V, Bostik P, Marek J. Soukup O, et al. Among authors: prchal l. Eur J Med Chem. 2020 Nov 15;206:112584. doi: 10.1016/j.ejmech.2020.112584. Epub 2020 Jul 19. Eur J Med Chem. 2020. PMID: 32853858
7-phenoxytacrine is a dually acting drug with neuroprotective efficacy in vivo.
Kaniakova M, Korabecny J, Holubova K, Kleteckova L, Chvojkova M, Hakenova K, Prchal L, Novak M, Dolezal R, Hepnarova V, Svobodova B, Kucera T, Lichnerova K, Krausova B, Horak M, Vales K, Soukup O. Kaniakova M, et al. Among authors: prchal l. Biochem Pharmacol. 2021 Apr;186:114460. doi: 10.1016/j.bcp.2021.114460. Epub 2021 Feb 8. Biochem Pharmacol. 2021. PMID: 33571502
47 results