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Iron-withdrawing anti-infectives for new host-directed therapies based on iron dependence, the Achilles' heel of antibiotic-resistant microbes.
Environ Chem Lett. 2021;19(4):2789-2808. doi: 10.1007/s10311-021-01242-7. Epub 2021 Apr 23.
Environ Chem Lett. 2021.
PMID: 33907538
Free PMC article.
Review.
DIBI, a 3-hydroxypyridin-4-one chelator iron-binding polymer with enhanced antimicrobial activity.
Ang MTC, Gumbau-Brisa R, Allan DS, McDonald R, Ferguson MJ, Holbein BE, Bierenstiel M.
Ang MTC, et al.
Medchemcomm. 2018 Jun 18;9(7):1206-1212. doi: 10.1039/c8md00192h. eCollection 2018 Jul 1.
Medchemcomm. 2018.
PMID: 30109009
Free PMC article.
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Antibiotic-Resistant Acinetobacter baumannii Is Susceptible to the Novel Iron-Sequestering Anti-infective DIBI In Vitro and in Experimental Pneumonia in Mice.
Parquet MDC, Savage KA, Allan DS, Ang MTC, Chen W, Logan SM, Holbein BE.
Parquet MDC, et al. Among authors: ang mtc.
Antimicrob Agents Chemother. 2019 Aug 23;63(9):e00855-19. doi: 10.1128/AAC.00855-19. Print 2019 Sep.
Antimicrob Agents Chemother. 2019.
PMID: 31209004
Free PMC article.
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Enhanced Fe3+ binding through cooperativity of 3-hydroxypyridin-4-one groups within a linear co-polymer: wrapping effect leading to superior antimicrobial activity.
Gumbau-Brisa R, Ang MTC, Holbein BE, Bierenstiel M.
Gumbau-Brisa R, et al. Among authors: ang mtc.
Biometals. 2020 Dec;33(6):339-351. doi: 10.1007/s10534-020-00253-1. Epub 2020 Oct 19.
Biometals. 2020.
PMID: 33074473
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Structure and spectroscopic properties of N,S-coordinating 2-methyl-sulfanyl-N-[(1H-pyrrol-2-yl)methyl-idene]aniline methanol monosolvate.
Richards DD, Ang MT, McDonald R, Bierenstiel M.
Richards DD, et al.
Acta Crystallogr E Crystallogr Commun. 2015 Sep 12;71(Pt 10):1136-9. doi: 10.1107/S205698901501590X. eCollection 2015 Oct 1.
Acta Crystallogr E Crystallogr Commun. 2015.
PMID: 26594390
Free PMC article.
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