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Dose escalation and expansion phase I studies with the tumour-targeting antibody-tumour necrosis factor fusion protein L19TNF plus doxorubicin in patients with advanced tumours, including sarcomas.
Schliemann C, Hemmerle T, Berdel AF, Angenendt L, Kerkhoff A, Hering JP, Heindel W, Hartmann W, Wardelmann E, Chawla SP, de Braud F, Lenz G, Neri D, Kessler T, Berdel WE. Schliemann C, et al. Among authors: hartmann w. Eur J Cancer. 2021 Jun;150:143-154. doi: 10.1016/j.ejca.2021.03.038. Epub 2021 Apr 23. Eur J Cancer. 2021. PMID: 33901793 Clinical Trial.
Phosphatidylinositol-3'-kinase/AKT signaling is essential in synovial sarcoma.
Friedrichs N, Trautmann M, Endl E, Sievers E, Kindler D, Wurst P, Czerwitzki J, Steiner S, Renner M, Penzel R, Koch A, Larsson O, Tanaka S, Kawai A, Schirmacher P, Mechtersheimer G, Wardelmann E, Buettner R, Hartmann W. Friedrichs N, et al. Among authors: hartmann w. Int J Cancer. 2011 Oct 1;129(7):1564-75. doi: 10.1002/ijc.25829. Epub 2011 Mar 4. Int J Cancer. 2011. PMID: 21128248 Free article.
MicroRNA profiling of primary high-grade soft tissue sarcomas.
Renner M, Czwan E, Hartmann W, Penzel R, Brors B, Eils R, Wardelmann E, Büttner R, Lichter P, Schirmacher P, Mechtersheimer G. Renner M, et al. Among authors: hartmann w. Genes Chromosomes Cancer. 2012 Nov;51(11):982-96. doi: 10.1002/gcc.21980. Epub 2012 Jul 18. Genes Chromosomes Cancer. 2012. PMID: 22811003
SRC signaling is crucial in the growth of synovial sarcoma cells.
Michels S, Trautmann M, Sievers E, Kindler D, Huss S, Renner M, Friedrichs N, Kirfel J, Steiner S, Endl E, Wurst P, Heukamp L, Penzel R, Larsson O, Kawai A, Tanaka S, Sonobe H, Schirmacher P, Mechtersheimer G, Wardelmann E, Büttner R, Hartmann W. Michels S, et al. Among authors: hartmann w. Cancer Res. 2013 Apr 15;73(8):2518-28. doi: 10.1158/0008-5472.CAN-12-3023. Epub 2013 Apr 11. Cancer Res. 2013. PMID: 23580575
A subset of gastrointestinal stromal tumors previously regarded as wild-type tumors carries somatic activating mutations in KIT exon 8 (p.D419del).
Huss S, Künstlinger H, Wardelmann E, Kleine MA, Binot E, Merkelbach-Bruse S, Rüdiger T, Mittler J, Hartmann W, Büttner R, Schildhaus HU. Huss S, et al. Among authors: hartmann w. Mod Pathol. 2013 Jul;26(7):1004-12. doi: 10.1038/modpathol.2013.47. Epub 2013 Apr 19. Mod Pathol. 2013. PMID: 23599150 Free PMC article.
Gastrointestinal stromal tumors with KIT exon 9 mutations: Update on genotype-phenotype correlation and validation of a high-resolution melting assay for mutational testing.
Künstlinger H, Huss S, Merkelbach-Bruse S, Binot E, Kleine MA, Loeser H, Mittler J, Hartmann W, Hohenberger P, Reichardt P, Büttner R, Wardelmann E, Schildhaus HU. Künstlinger H, et al. Among authors: hartmann w. Am J Surg Pathol. 2013 Nov;37(11):1648-59. doi: 10.1097/PAS.0b013e3182986b88. Am J Surg Pathol. 2013. PMID: 24061512
TERT promoter hotspot mutations are recurrent in myxoid liposarcomas but rare in other soft tissue sarcoma entities.
Koelsche C, Renner M, Hartmann W, Brandt R, Lehner B, Waldburger N, Alldinger I, Schmitt T, Egerer G, Penzel R, Wardelmann E, Schirmacher P, von Deimling A, Mechtersheimer G. Koelsche C, et al. Among authors: hartmann w. J Exp Clin Cancer Res. 2014 Apr 11;33(1):33. doi: 10.1186/1756-9966-33-33. J Exp Clin Cancer Res. 2014. PMID: 24726063 Free PMC article.
611 results