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Sphingosine Kinase 1/S1P Signaling Contributes to Pulmonary Fibrosis by Activating Hippo/YAP Pathway and Mitochondrial Reactive Oxygen Species in Lung Fibroblasts.
Huang LS, Sudhadevi T, Fu P, Punathil-Kannan PK, Ebenezer DL, Ramchandran R, Putherickal V, Cheresh P, Zhou G, Ha AW, Harijith A, Kamp DW, Natarajan V. Huang LS, et al. Among authors: ebenezer dl. Int J Mol Sci. 2020 Mar 17;21(6):2064. doi: 10.3390/ijms21062064. Int J Mol Sci. 2020. PMID: 32192225 Free PMC article.
Neonatal therapy with PF543, a sphingosine kinase 1 inhibitor, ameliorates hyperoxia-induced airway remodeling in a murine model of bronchopulmonary dysplasia.
Ha AW, Sudhadevi T, Ebenezer DL, Fu P, Berdyshev EV, Ackerman SJ, Natarajan V, Harijith A. Ha AW, et al. Among authors: ebenezer dl. Am J Physiol Lung Cell Mol Physiol. 2020 Sep 1;319(3):L497-L512. doi: 10.1152/ajplung.00169.2020. Epub 2020 Jul 22. Am J Physiol Lung Cell Mol Physiol. 2020. PMID: 32697651 Free PMC article.
Sphingosine-1-phosphate lyase is an endogenous suppressor of pulmonary fibrosis: role of S1P signalling and autophagy.
Huang LS, Berdyshev EV, Tran JT, Xie L, Chen J, Ebenezer DL, Mathew B, Gorshkova I, Zhang W, Reddy SP, Harijith A, Wang G, Feghali-Bostwick C, Noth I, Ma SF, Zhou T, Ma W, Garcia JG, Natarajan V. Huang LS, et al. Among authors: ebenezer dl. Thorax. 2015 Dec;70(12):1138-48. doi: 10.1136/thoraxjnl-2014-206684. Epub 2015 Aug 18. Thorax. 2015. PMID: 26286721 Free article.
Hyperoxia-induced p47phox activation and ROS generation is mediated through S1P transporter Spns2, and S1P/S1P1&2 signaling axis in lung endothelium.
Harijith A, Pendyala S, Ebenezer DL, Ha AW, Fu P, Wang YT, Ma K, Toth PT, Berdyshev EV, Kanteti P, Natarajan V. Harijith A, et al. Among authors: ebenezer dl. Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L337-51. doi: 10.1152/ajplung.00447.2015. Epub 2016 Jun 24. Am J Physiol Lung Cell Mol Physiol. 2016. PMID: 27343196 Free PMC article.
Targeting sphingosine-1-phosphate signaling in lung diseases.
Ebenezer DL, Fu P, Natarajan V. Ebenezer DL, et al. Pharmacol Ther. 2016 Dec;168:143-157. doi: 10.1016/j.pharmthera.2016.09.008. Epub 2016 Sep 13. Pharmacol Ther. 2016. PMID: 27621206 Free PMC article. Review.
25 results