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PPARγ-induced upregulation of subcutaneous fat adiponectin secretion, glyceroneogenesis and BCAA oxidation requires mTORC1 activity.
Andrade ML, Gilio GR, Perandini LA, Peixoto AS, Moreno MF, Castro É, Oliveira TE, Vieira TS, Ortiz-Silva M, Thomazelli CA, Chaves-Filho AB, Belchior T, Chimin P, Magdalon J, Ivison R, Pant D, Tsai L, Yoshinaga MY, Miyamoto S, Festuccia WT. Andrade ML, et al. Among authors: festuccia wt. Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Aug;1866(8):158967. doi: 10.1016/j.bbalip.2021.158967. Epub 2021 May 15. Biochim Biophys Acta Mol Cell Biol Lipids. 2021. PMID: 34004356 Free PMC article.
Adipocyte-specific mTORC2 deficiency impairs BAT and iWAT thermogenic capacity without affecting glucose uptake and energy expenditure in cold-acclimated mice.
Castro É, Vieira TS, Oliveira TE, Ortiz-Silva M, Andrade ML, Tomazelli CA, Peixoto AS, Sobrinho CR, Moreno MF, Gilio GR, Moreira RJ, Guimarães RC, Perandini LA, Chimin P, Reckziegel P, Moretti EH, Steiner AA, Laplante M, Festuccia WT. Castro É, et al. Among authors: festuccia wt. Am J Physiol Endocrinol Metab. 2021 Nov 1;321(5):E592-E605. doi: 10.1152/ajpendo.00587.2020. Epub 2021 Sep 20. Am J Physiol Endocrinol Metab. 2021. PMID: 34541875 Free article.
Futile cycle of β-oxidation and de novo lipogenesis are associated with essential fatty acids depletion in lipoatrophy.
Chaves-Filho AB, Peixoto AS, Castro É, Oliveira TE, Perandini LA, Moreira RJ, da Silva RP, da Silva BP, Moretti EH, Steiner AA, Miyamoto S, Yoshinaga MY, Festuccia WT. Chaves-Filho AB, et al. Among authors: festuccia wt. Biochim Biophys Acta Mol Cell Biol Lipids. 2023 Mar;1868(3):159264. doi: 10.1016/j.bbalip.2022.159264. Epub 2022 Dec 17. Biochim Biophys Acta Mol Cell Biol Lipids. 2023. PMID: 36535597
Tributyrin attenuates obesity-associated inflammation and insulin resistance in high-fat-fed mice.
Vinolo MA, Rodrigues HG, Festuccia WT, Crisma AR, Alves VS, Martins AR, Amaral CL, Fiamoncini J, Hirabara SM, Sato FT, Fock RA, Malheiros G, dos Santos MF, Curi R. Vinolo MA, et al. Among authors: festuccia wt. Am J Physiol Endocrinol Metab. 2012 Jul 15;303(2):E272-82. doi: 10.1152/ajpendo.00053.2012. Epub 2012 May 22. Am J Physiol Endocrinol Metab. 2012. PMID: 22621868 Free article.
Constitutive Activation of the Nutrient Sensor mTORC1 in Myeloid Cells Induced by Tsc1 Deletion Protects Mice from Diet-Induced Obesity.
Paschoal VA, Belchior T, Amano MT, Burgos-Silva M, Peixoto AS, Magdalon J, Vieira TS, Andrade ML, Moreno MF, Chimin P, Câmara NO, Festuccia WT. Paschoal VA, et al. Among authors: festuccia wt. Mol Nutr Food Res. 2018 Sep;62(17):e1800283. doi: 10.1002/mnfr.201800283. Epub 2018 Aug 8. Mol Nutr Food Res. 2018. PMID: 30001482
Loss of mTORC2 Activity in Neutrophils Impairs Fusion of Granules and Affects Cellular Metabolism Favoring Increased Bacterial Burden in Sepsis.
Breda CNS, Breda LCD, Carvalho LADC, Amano MT, Terra FF, Silva RC, Fragas MG, Forni MF, Fonseca MTC, Venturini G, Feitosa ACM, Ghirotto B, Cruz MC, Cunha FF, Ignacio A, Latância M, Castoldi A, Andrade-Oliveira V, Martins da Silva E, Hiyane MI, Pereira ADC, Festuccia W, Meotti FC, Câmara NOS. Breda CNS, et al. J Immunol. 2021 Jul 15;207(2):626-639. doi: 10.4049/jimmunol.2000573. Epub 2021 Jul 14. J Immunol. 2021. PMID: 34261666
mTORC1 inhibition with rapamycin exacerbates adipose tissue inflammation in obese mice and dissociates macrophage phenotype from function.
Paschoal VA, Amano MT, Belchior T, Magdalon J, Chimin P, Andrade ML, Ortiz-Silva M, Castro É, Yamashita AS, Rosa Neto JC, Câmara NO, Festuccia WT. Paschoal VA, et al. Among authors: festuccia wt. Immunobiology. 2017 Feb;222(2):261-271. doi: 10.1016/j.imbio.2016.09.014. Epub 2016 Sep 28. Immunobiology. 2017. PMID: 27692982
98 results