Thyer R - Search Results

1

Directed Evolution of an Improved Aminoacyl-tRNA Synthetase for Incorporation of L-3,4-Dihydroxyphenylalanine (L-DOPA).

Thyer R, d'Oelsnitz S, Blevins MS, Klein DR, Brodbelt JS, Ellington AD. Thyer R, et al. Angew Chem Int Ed Engl. 2021 Jun 25;60(27):14811-14816. doi: 10.1002/anie.202100579. Epub 2021 May 24. Angew Chem Int Ed Engl. 2021. PMID: 33871147 Free PMC article.

2

Evolving tRNA(Sec) for efficient canonical incorporation of selenocysteine.

Thyer R, Robotham SA, Brodbelt JS, Ellington AD. Thyer R, et al. J Am Chem Soc. 2015 Jan 14;137(1):46-9. doi: 10.1021/ja510695g. Epub 2014 Dec 23. J Am Chem Soc. 2015. PMID: 25521771 Free PMC article.

3

Structural Characterization of Dihydrofolate Reductase Complexes by Top-Down Ultraviolet Photodissociation Mass Spectrometry.

Cammarata MB, Thyer R, Rosenberg J, Ellington A, Brodbelt JS. Cammarata MB, et al. Among authors: thyer r. J Am Chem Soc. 2015 Jul 22;137(28):9128-35. doi: 10.1021/jacs.5b04628. Epub 2015 Jul 9. J Am Chem Soc. 2015. PMID: 26125523

4

Addicting diverse bacteria to a noncanonical amino acid.

Tack DS, Ellefson JW, Thyer R, Wang B, Gollihar J, Forster MT, Ellington AD. Tack DS, et al. Among authors: thyer r. Nat Chem Biol. 2016 Mar;12(3):138-40. doi: 10.1038/nchembio.2002. Epub 2016 Jan 18. Nat Chem Biol. 2016. PMID: 26780407

5

Correction to "Structural Characterization of Dihydrofolate Reductase Complexes by Top-Down Ultraviolet Photodissociation Mass Spectrometry".

Cammarata MB, Thyer R, Rosenberg J, Ellington A, Brodbelt JS. Cammarata MB, et al. Among authors: thyer r. J Am Chem Soc. 2016 Mar 9;138(9):3252. doi: 10.1021/jacs.6b01611. Epub 2016 Feb 26. J Am Chem Soc. 2016. PMID: 26919090 No abstract available.

6

Custom selenoprotein production enabled by laboratory evolution of recoded bacterial strains.

Thyer R, Shroff R, Klein DR, d'Oelsnitz S, Cotham VC, Byrom M, Brodbelt JS, Ellington AD. Thyer R, et al. Nat Biotechnol. 2018 Aug;36(7):624-631. doi: 10.1038/nbt.4154. Epub 2018 Jun 4. Nat Biotechnol. 2018. PMID: 29863724 Free PMC article.

7

Characterization of trimethoprim resistant E. coli dihydrofolate reductase mutants by mass spectrometry and inhibition by propargyl-linked antifolates.

Cammarata M, Thyer R, Lombardo M, Anderson A, Wright D, Ellington A, Brodbelt JS. Cammarata M, et al. Among authors: thyer r. Chem Sci. 2017 May 1;8(5):4062-4072. doi: 10.1039/c6sc05235e. Epub 2017 Mar 28. Chem Sci. 2017. PMID: 29967675 Free PMC article.

8

The Role of tRNA in Establishing New Genetic Codes.

Thyer R, Ellington AD. Thyer R, et al. Biochemistry. 2019 Mar 19;58(11):1460-1463. doi: 10.1021/acs.biochem.8b00834. Epub 2018 Nov 14. Biochemistry. 2019. PMID: 30387992

9

Discovery of Novel Gain-of-Function Mutations Guided by Structure-Based Deep Learning.

Shroff R, Cole AW, Diaz DJ, Morrow BR, Donnell I, Annapareddy A, Gollihar J, Ellington AD, Thyer R. Shroff R, et al. Among authors: thyer r. ACS Synth Biol. 2020 Nov 20;9(11):2927-2935. doi: 10.1021/acssynbio.0c00345. Epub 2020 Oct 16. ACS Synth Biol. 2020. PMID: 33064458

10

Using fungible biosensors to evolve improved alkaloid biosyntheses.

d'Oelsnitz S, Kim W, Burkholder NT, Javanmardi K, Thyer R, Zhang Y, Alper HS, Ellington AD. d'Oelsnitz S, et al. Among authors: thyer r. Nat Chem Biol. 2022 Sep;18(9):981-989. doi: 10.1038/s41589-022-01072-w. Epub 2022 Jul 7. Nat Chem Biol. 2022. PMID: 35799063

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