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6-Methyl-7-Aryl-7-Deazapurine Nucleosides as Anti-Trypanosoma cruzi Agents: Structure-Activity Relationship and in vivo Efficacy.
Lin C, Ferreira de Almeida Fiuza L, Cardoso Santos C, Ferreira Nunes D, Cruz Moreira O, Bouton J, Karalic I, Maes L, Caljon G, Hulpia F, de Nazaré C Soeiro M, Van Calenbergh S. Lin C, et al. Among authors: cruz moreira o. ChemMedChem. 2021 Jul 20;16(14):2231-2253. doi: 10.1002/cmdc.202100144. Epub 2021 May 13. ChemMedChem. 2021. PMID: 33856742
7-Aryl-7-deazapurine 3'-deoxyribonucleoside derivative as a novel lead for Chagas' disease therapy: in vitro and in vivo pharmacology.
Cardoso-Santos C, Ferreira de Almeida Fiuza L, França da Silva C, Mazzeti AL, Donola Girão R, Melo de Oliveira G, da Gama Jaen Batista D, Cruz Moreira O, Lins da Silva Gomes N, Maes L, Caljon G, Hulpia F, Calenbergh SV, Correia Soeiro MN. Cardoso-Santos C, et al. Among authors: cruz moreira o. JAC Antimicrob Resist. 2021 Nov 17;3(4):dlab168. doi: 10.1093/jacamr/dlab168. eCollection 2021 Dec. JAC Antimicrob Resist. 2021. PMID: 34806007 Free PMC article.
Memory impairment in chronic experimental Chagas disease: Benznidazole therapy reversed cognitive deficit in association with reduction of parasite load and oxidative stress in the nervous tissue.
Vilar-Pereira G, Castaño Barrios L, Silva AAD, Martins Batista A, Resende Pereira I, Cruz Moreira O, Britto C, Mata Dos Santos HA, Lannes-Vieira J. Vilar-Pereira G, et al. Among authors: cruz moreira o. PLoS One. 2021 Jan 5;16(1):e0244710. doi: 10.1371/journal.pone.0244710. eCollection 2021. PLoS One. 2021. PMID: 33400707 Free PMC article.
Combination Chemotherapy with Suboptimal Doses of Benznidazole and Pentoxifylline Sustains Partial Reversion of Experimental Chagas' Heart Disease.
Vilar-Pereira G, Resende Pereira I, de Souza Ruivo LA, Cruz Moreira O, da Silva AA, Britto C, Lannes-Vieira J. Vilar-Pereira G, et al. Among authors: cruz moreira o. Antimicrob Agents Chemother. 2016 Jun 20;60(7):4297-309. doi: 10.1128/AAC.02123-15. Print 2016 Jul. Antimicrob Agents Chemother. 2016. PMID: 27161638 Free PMC article.
The beneficial effect of fluoxetine on behavioral and cognitive changes in chronic experimental Chagas disease unveils the role of serotonin fueling astrocyte infection by Trypanosoma cruzi.
Vilar-Pereira G, Gibaldi D, Castaño-Barrios L, da Silva AA, Resende Pereira I, Cruz Moreira O, Britto C, Mata Dos Santos HA, de Oliveira Lopes R, Wanderley Tinoco L, Oliveira W Jr, Lannes-Vieira J. Vilar-Pereira G, et al. Among authors: cruz moreira o. PLoS Negl Trop Dis. 2024 May 22;18(5):e0012199. doi: 10.1371/journal.pntd.0012199. eCollection 2024 May. PLoS Negl Trop Dis. 2024. PMID: 38776344 Free PMC article.
TGF-β inhibitor therapy decreases fibrosis and stimulates cardiac improvement in a pre-clinical study of chronic Chagas' heart disease.
Ferreira RR, Abreu RDS, Vilar-Pereira G, Degrave W, Meuser-Batista M, Ferreira NVC, da Cruz Moreira O, da Silva Gomes NL, Mello de Souza E, Ramos IP, Bailly S, Feige JJ, Lannes-Vieira J, de Araújo-Jorge TC, Waghabi MC. Ferreira RR, et al. Among authors: da cruz moreira o. PLoS Negl Trop Dis. 2019 Jul 31;13(7):e0007602. doi: 10.1371/journal.pntd.0007602. eCollection 2019 Jul. PLoS Negl Trop Dis. 2019. PMID: 31365537 Free PMC article.
Impact of levamisole in co-administration with benznidazole on experimental Chagas disease.
Rocha Simões-Silva M, Brandão Peres R, Britto C, Machado Cascabulho C, de Melo Oliveira G, Nefertiti da Gama A, França da Silva C, Lima da Costa K, Finamore Araújo P, Diego de Souza Campos J, Meuser Batista M, Cristina Demarque K, da Cruz Moreira O, de Nazaré Correia Soeiro M. Rocha Simões-Silva M, et al. Among authors: da cruz moreira o. Parasitology. 2019 Jul;146(8):1055-1062. doi: 10.1017/S0031182019000374. Epub 2019 May 3. Parasitology. 2019. PMID: 31046850
Analytical Validation of Quantitative Real-Time PCR Methods for Quantification of Trypanosoma cruzi DNA in Blood Samples from Chagas Disease Patients.
Ramírez JC, Cura CI, da Cruz Moreira O, Lages-Silva E, Juiz N, Velázquez E, Ramírez JD, Alberti A, Pavia P, Flores-Chávez MD, Muñoz-Calderón A, Pérez-Morales D, Santalla J, Marcos da Matta Guedes P, Peneau J, Marcet P, Padilla C, Cruz-Robles D, Valencia E, Crisante GE, Greif G, Zulantay I, Costales JA, Alvarez-Martínez M, Martínez NE, Villarroel R, Villarroel S, Sánchez Z, Bisio M, Parrado R, Maria da Cunha Galvão L, Jácome da Câmara AC, Espinoza B, Alarcón de Noya B, Puerta C, Riarte A, Diosque P, Sosa-Estani S, Guhl F, Ribeiro I, Aznar C, Britto C, Yadón ZE, Schijman AG. Ramírez JC, et al. Among authors: da cruz moreira o. J Mol Diagn. 2015 Sep;17(5):605-15. doi: 10.1016/j.jmoldx.2015.04.010. J Mol Diagn. 2015. PMID: 26320872 Free PMC article.
11 results