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Antibody disulfide bond reduction and recovery during biopharmaceutical process development-A review.
Biotechnol Bioeng. 2021 Aug;118(8):2829-2844. doi: 10.1002/bit.27790. Epub 2021 Jun 1.
Biotechnol Bioeng. 2021.
PMID: 33844277
Review.
Online/at-line measurement, analysis and control of product titer and critical product quality attributes (CQAs) during process development.
Chemmalil L, Prabhakar T, Kuang J, West J, Tan Z, Ehamparanathan V, Song Y, Xu J, Ding J, Li Z.
Chemmalil L, et al. Among authors: ehamparanathan v.
Biotechnol Bioeng. 2020 Dec;117(12):3757-3765. doi: 10.1002/bit.27531. Epub 2020 Aug 24.
Biotechnol Bioeng. 2020.
PMID: 32776503
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On-column disulfide bond formation of monoclonal antibodies during Protein A chromatography eliminates low molecular weight species and rescues reduced antibodies.
Tan Z, Ehamparanathan V, Ren T, Tang P, Hoffman L, Kuang J, Liu P, Huang C, Du C, Tao L, Chemmalil L, Lewandowski A, Ghose S, Li ZJ, Liu S.
Tan Z, et al. Among authors: ehamparanathan v.
MAbs. 2020 Jan-Dec;12(1):1829333. doi: 10.1080/19420862.2020.1829333.
MAbs. 2020.
PMID: 33016217
Free PMC article.
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Optimization and kinetic modeling of interchain disulfide bond reoxidation of monoclonal antibodies in bioprocesses.
Tang P, Tan Z, Ehamparanathan V, Ren T, Hoffman L, Du C, Song Y, Tao L, Lewandowski A, Ghose S, Li ZJ, Liu S.
Tang P, et al. Among authors: ehamparanathan v.
MAbs. 2020 Jan-Dec;12(1):1829336. doi: 10.1080/19420862.2020.1829336.
MAbs. 2020.
PMID: 33031716
Free PMC article.
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