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Design, synthesis, and biological evaluation of novel deguelin-based heat shock protein 90 (HSP90) inhibitors targeting proliferation and angiogenesis.
Chang DJ, An H, Kim KS, Kim HH, Jung J, Lee JM, Kim NJ, Han YT, Yun H, Lee S, Lee G, Lee S, Lee JS, Cha JH, Park JH, Park JW, Lee SC, Kim SG, Kim JH, Lee HY, Kim KW, Suh YG. Chang DJ, et al. Among authors: lee g, lee js, lee hy, lee sc, lee jm, lee s. J Med Chem. 2012 Dec 27;55(24):10863-84. doi: 10.1021/jm301488q. Epub 2012 Dec 7. J Med Chem. 2012. PMID: 23186287
Deguelin Analogue SH-1242 Inhibits Hsp90 Activity and Exerts Potent Anticancer Efficacy with Limited Neurotoxicity.
Lee SC, Min HY, Choi H, Bae SY, Park KH, Hyun SY, Lee HJ, Moon J, Park SH, Kim JY, An H, Park SJ, Seo JH, Lee S, Kim YM, Park HJ, Lee SK, Lee J, Lee J, Kim KW, Suh YG, Lee HY. Lee SC, et al. Among authors: lee sk, lee j, lee hy, lee s, lee hj. Cancer Res. 2016 Feb 1;76(3):686-99. doi: 10.1158/0008-5472.CAN-15-1492. Epub 2015 Dec 8. Cancer Res. 2016. PMID: 26645561
Novel Hypoxia-Inducible Factor 1α (HIF-1α) Inhibitors for Angiogenesis-Related Ocular Diseases: Discovery of a Novel Scaffold via Ring-Truncation Strategy.
An H, Lee S, Lee JM, Jo DH, Kim J, Jeong YS, Heo MJ, Cho CS, Choi H, Seo JH, Hwang S, Lim J, Kim T, Jun HO, Sim J, Lim C, Hur J, Ahn J, Kim HS, Seo SY, Na Y, Kim SH, Lee J, Lee J, Chung SJ, Kim YM, Kim KW, Kim SG, Kim JH, Suh YG. An H, et al. Among authors: lee j, lee s, lee jm. J Med Chem. 2018 Oct 25;61(20):9266-9286. doi: 10.1021/acs.jmedchem.8b00971. Epub 2018 Oct 9. J Med Chem. 2018. PMID: 30252468
Investigation of B,C-ring truncated deguelin derivatives as heat shock protein 90 (HSP90) inhibitors for use as anti-breast cancer agents.
Kim HS, Hoang VH, Hong M, Chul Kim K, Ann J, Nguyen CT, Seo JH, Choi H, Yong Kim J, Kim KW, Sub Byun W, Lee S, Lee S, Suh YG, Chen J, Park HJ, Cho TM, Kim JY, Seo JH, Lee J. Kim HS, et al. Among authors: lee j, lee s. Bioorg Med Chem. 2019 Apr 1;27(7):1370-1381. doi: 10.1016/j.bmc.2019.02.040. Epub 2019 Feb 20. Bioorg Med Chem. 2019. PMID: 30827868
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