Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

Search Results

10 results

Filters applied: . Clear all
Results are displayed in a computed author sort order. The Results By Year timeline is not available.
Page 1
Novel Specific Metallo-β-Lactamase Inhibitor ANT2681 Restores Meropenem Activity to Clinically Effective Levels against NDM-Positive Enterobacterales.
Zalacain M, Lozano C, Llanos A, Sprynski N, Valmont T, De Piano C, Davies D, Leiris S, Sable C, Ledoux A, Morrissey I, Lemonnier M, Everett M. Zalacain M, et al. Among authors: sprynski n. Antimicrob Agents Chemother. 2021 May 18;65(6):e00203-21. doi: 10.1128/AAC.00203-21. Print 2021 May 18. Antimicrob Agents Chemother. 2021. PMID: 33820763 Free PMC article.
Discovery of a Novel Metallo-β-Lactamase Inhibitor That Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacteriaceae.
Everett M, Sprynski N, Coelho A, Castandet J, Bayet M, Bougnon J, Lozano C, Davies DT, Leiris S, Zalacain M, Morrissey I, Magnet S, Holden K, Warn P, De Luca F, Docquier JD, Lemonnier M. Everett M, et al. Among authors: sprynski n. Antimicrob Agents Chemother. 2018 Apr 26;62(5):e00074-18. doi: 10.1128/AAC.00074-18. Print 2018 May. Antimicrob Agents Chemother. 2018. PMID: 29530861 Free PMC article.
SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model.
Leiris S, Coelho A, Castandet J, Bayet M, Lozano C, Bougnon J, Bousquet J, Everett M, Lemonnier M, Sprynski N, Zalacain M, Pallin TD, Cramp MC, Jennings N, Raphy G, Jones MW, Pattipati R, Shankar B, Sivasubrahmanyam R, Soodhagani AK, Juventhala RR, Pottabathini N, Pothukanuri S, Benvenuti M, Pozzi C, Mangani S, De Luca F, Cerboni G, Docquier JD, Davies DT. Leiris S, et al. Among authors: sprynski n. ACS Infect Dis. 2019 Jan 11;5(1):131-140. doi: 10.1021/acsinfecdis.8b00246. Epub 2018 Nov 30. ACS Infect Dis. 2019. PMID: 30427656 Free PMC article.
ANT2681: SAR Studies Leading to the Identification of a Metallo-β-lactamase Inhibitor with Potential for Clinical Use in Combination with Meropenem for the Treatment of Infections Caused by NDM-Producing Enterobacteriaceae.
Davies DT, Leiris S, Sprynski N, Castandet J, Lozano C, Bousquet J, Zalacain M, Vasa S, Dasari PK, Pattipati R, Vempala N, Gujjewar S, Godi S, Jallala R, Sathyap RR, Darshanoju NA, Ravu VR, Juventhala RR, Pottabathini N, Sharma S, Pothukanuri S, Holden K, Warn P, Marcoccia F, Benvenuti M, Pozzi C, Mangani S, Docquier JD, Lemonnier M, Everett M. Davies DT, et al. Among authors: sprynski n. ACS Infect Dis. 2020 Sep 11;6(9):2419-2430. doi: 10.1021/acsinfecdis.0c00207. Epub 2020 Aug 20. ACS Infect Dis. 2020. PMID: 32786279
Discovery of ANT3310, a Novel Broad-Spectrum Serine β-Lactamase Inhibitor of the Diazabicyclooctane Class, Which Strongly Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacterales and Acinetobacter baumannii.
Davies DT, Leiris S, Zalacain M, Sprynski N, Castandet J, Bousquet J, Lozano C, Llanos A, Alibaud L, Vasa S, Pattipati R, Valige R, Kummari B, Pothukanuri S, De Piano C, Morrissey I, Holden K, Warn P, Marcoccia F, Benvenuti M, Pozzi C, Tassone G, Mangani S, Docquier JD, Pallin D, Elliot R, Lemonnier M, Everett M. Davies DT, et al. Among authors: sprynski n. J Med Chem. 2020 Dec 24;63(24):15802-15820. doi: 10.1021/acs.jmedchem.0c01535. Epub 2020 Dec 11. J Med Chem. 2020. PMID: 33306385
Pseudomonas aeruginosa Elastase Contributes to the Establishment of Chronic Lung Colonization and Modulates the Immune Response in a Murine Model.
Cigana C, Castandet J, Sprynski N, Melessike M, Beyria L, Ranucci S, Alcalá-Franco B, Rossi A, Bragonzi A, Zalacain M, Everett M. Cigana C, et al. Among authors: sprynski n. Front Microbiol. 2021 Jan 12;11:620819. doi: 10.3389/fmicb.2020.620819. eCollection 2020. Front Microbiol. 2021. PMID: 33510733 Free PMC article.
Virtual Screening Approach to Identifying a Novel and Tractable Series of Pseudomonas aeruginosa Elastase Inhibitors.
Leiris S, Davies DT, Sprynski N, Castandet J, Beyria L, Bodnarchuk MS, Sutton JM, Mullins TMG, Jones MW, Forrest AK, Pallin TD, Karunakar P, Martha SK, Parusharamulu B, Ramula R, Kotha V, Pottabathini N, Pothukanuri S, Lemonnier M, Everett M. Leiris S, et al. Among authors: sprynski n. ACS Med Chem Lett. 2021 Jan 15;12(2):217-227. doi: 10.1021/acsmedchemlett.0c00554. eCollection 2021 Feb 11. ACS Med Chem Lett. 2021. PMID: 33603968 Free PMC article.
Chemical Optimization of Selective Pseudomonas aeruginosa LasB Elastase Inhibitors and Their Impact on LasB-Mediated Activation of IL-1β in Cellular and Animal Infection Models.
Everett MJ, Davies DT, Leiris S, Sprynski N, Llanos A, Castandet JM, Lozano C, LaRock CN, LaRock DL, Corsica G, Docquier JD, Pallin TD, Cridland A, Blench T, Zalacain M, Lemonnier M. Everett MJ, et al. Among authors: sprynski n. ACS Infect Dis. 2023 Feb 10;9(2):270-282. doi: 10.1021/acsinfecdis.2c00418. Epub 2023 Jan 20. ACS Infect Dis. 2023. PMID: 36669138 Free PMC article.