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A Novel Precision Approach to Overcome the "Addiction Pandemic" by Incorporating Genetic Addiction Risk Severity (GARS) and Dopamine Homeostasis Restoration.
Blum K, Kazmi S, Modestino EJ, Downs BW, Bagchi D, Baron D, McLaughlin T, Green R, Jalali R, Thanos PK, Elman I, Badgaiyan RD, Bowirrat A, Gold MS. Blum K, et al. Among authors: downs bw. J Pers Med. 2021 Mar 16;11(3):212. doi: 10.3390/jpm11030212. J Pers Med. 2021. PMID: 33809702 Free PMC article. Review.
Neurogenetics of dopaminergic receptor supersensitivity in activation of brain reward circuitry and relapse: proposing "deprivation-amplification relapse therapy" (DART).
Blum K, Chen TJ, Downs BW, Bowirrat A, Waite RL, Braverman ER, Madigan M, Oscar-Berman M, DiNubile N, Stice E, Giordano J, Morse S, Gold M. Blum K, et al. Among authors: downs bw. Postgrad Med. 2009 Nov;121(6):176-96. doi: 10.3810/pgm.2009.11.2087. Postgrad Med. 2009. PMID: 19940429 Free PMC article. Review.
Acute intravenous synaptamine complex variant KB220™ "normalizes" neurological dysregulation in patients during protracted abstinence from alcohol and opiates as observed using quantitative electroencephalographic and genetic analysis for reward polymorphisms: part 1, pilot study with 2 case reports.
Miller DK, Bowirrat A, Manka M, Miller M, Stokes S, Manka D, Allen C, Gant C, Downs BW, Smolen A, Stevens E, Yeldandi S, Blum K. Miller DK, et al. Among authors: downs bw. Postgrad Med. 2010 Nov;122(6):188-213. doi: 10.3810/pgm.2010.11.2236. Postgrad Med. 2010. PMID: 21084795 Review.
Neuro-psychopharmacogenetics and Neurological Antecedents of Posttraumatic Stress Disorder: Unlocking the Mysteries of Resilience and Vulnerability.
Bowirrat A, Chen TJ, Blum K, Madigan M, Bailey JA, Chuan Chen AL, Downs BW, Braverman ER, Radi S, Waite RL, Kerner M, Giordano J, Morse S, Oscar-Berman M, Gold M. Bowirrat A, et al. Among authors: downs bw. Curr Neuropharmacol. 2010 Dec;8(4):335-58. doi: 10.2174/157015910793358123. Curr Neuropharmacol. 2010. PMID: 21629442 Free PMC article.
Can the chronic administration of the combination of buprenorphine and naloxone block dopaminergic activity causing anti-reward and relapse potential?
Blum K, Chen TJ, Bailey J, Bowirrat A, Femino J, Chen AL, Simpatico T, Morse S, Giordano J, Damle U, Kerner M, Braverman ER, Fornari F, Downs BW, Rector C, Barh D, Oscar-Berman M. Blum K, et al. Among authors: downs bw. Mol Neurobiol. 2011 Dec;44(3):250-68. doi: 10.1007/s12035-011-8206-0. Epub 2011 Sep 24. Mol Neurobiol. 2011. PMID: 21948099 Free PMC article.
"Dopamine homeostasis" requires balanced polypharmacy: Issue with destructive, powerful dopamine agents to combat America's drug epidemic.
Blum K, Modestino EJ, Gondré-Lewis M, Downs BW, Baron D, Steinberg B, Siwicki D, Giordano J, McLaughlin T, Neary J, Hauser M, Fried L, Badgaiyan RD. Blum K, et al. Among authors: downs bw. J Syst Integr Neurosci. 2017 Nov;3(6):10.15761/JSIN.1000183. doi: 10.15761/JSIN.1000183. Epub 2017 Nov 17. J Syst Integr Neurosci. 2017. PMID: 30197787 Free PMC article.
Would induction of dopamine homeostasis via coupling genetic addiction risk score (GARS®) and pro-dopamine regulation benefit benzodiazepine use disorder (BUD)?
Blum K, Gold M, Modestino EJ, Baron D, Boyett B, Siwicki D, Lott L, Podesta A, Roy AK, Hauser M, Downs BW, Badgaiyan RD. Blum K, et al. Among authors: downs bw. J Syst Integr Neurosci. 2018 May 3;4:10.15761/JSIN.1000196. doi: 10.15761/JSIN.1000196. J Syst Integr Neurosci. 2018. PMID: 31750006 Free PMC article.
79 results