Acetaminophen-induced liver injury is mediated by the ion channel TRPV4.
Echtermeyer F, Eberhardt M, Risser L, Herzog C, Gueler F, Khalil M, Engel M, Vondran F, Leffler A.
Echtermeyer F, et al. Among authors: leffler a.
FASEB J. 2019 Sep;33(9):10257-10268. doi: 10.1096/fj.201802233R. Epub 2019 Jun 17.
FASEB J. 2019.
PMID: 31207191
Both pharmacological inhibition and genetic deletion of TRPV4 ameliorate APAP-induced necrosis in mouse and human hepatocytes in vitro. Liver injury caused by a systemic overdose of APAP is reduced in TRPV4-deficient mice and in wild-type mice treated with a TRPV4 i …
Both pharmacological inhibition and genetic deletion of TRPV4 ameliorate APAP-induced necrosis in mouse and human hepatocytes in vitro. Live …