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The proneural gene ASCL1 governs the transcriptional subgroup affiliation in glioblastoma stem cells by directly repressing the mesenchymal gene NDRG1.
Narayanan A, Gagliardi F, Gallotti AL, Mazzoleni S, Cominelli M, Fagnocchi L, Pala M, Piras IS, Zordan P, Moretta N, Tratta E, Brugnara G, Altabella L, Bozzuto G, Gorombei P, Molinari A, Padua RA, Bulfone A, Politi LS, Falini A, Castellano A, Mortini P, Zippo A, Poliani PL, Galli R. Narayanan A, et al. Among authors: galli r. Cell Death Differ. 2019 Sep;26(9):1813-1831. doi: 10.1038/s41418-018-0248-7. Epub 2018 Dec 11. Cell Death Differ. 2019. PMID: 30538287 Free PMC article.
Enhanced SPARCL1 expression in cancer stem cells improves preclinical modeling of glioblastoma by promoting both tumor infiltration and angiogenesis.
Gagliardi F, Narayanan A, Gallotti AL, Pieri V, Mazzoleni S, Cominelli M, Rezzola S, Corsini M, Brugnara G, Altabella L, Politi LS, Bacigaluppi M, Falini A, Castellano A, Ronca R, Poliani PL, Mortini P, Galli R. Gagliardi F, et al. Among authors: galli r. Neurobiol Dis. 2020 Feb;134:104705. doi: 10.1016/j.nbd.2019.104705. Epub 2019 Dec 10. Neurobiol Dis. 2020. PMID: 31830525 Free article.
mTORC1 promotes malignant large cell/anaplastic histology and is a targetable vulnerability in SHH-TP53 mutant medulloblastoma.
Conti V, Cominelli M, Pieri V, Gallotti AL, Pagano I, Zanella M, Mazzoleni S, Pivetta F, Patanè M, Scotti GM, Piras IS, Pollo B, Falini A, Zippo A, Castellano A, Maestro R, Poliani PL, Galli R. Conti V, et al. Among authors: galli r. JCI Insight. 2021 Dec 8;6(23):e153462. doi: 10.1172/jci.insight.153462. JCI Insight. 2021. PMID: 34673573 Free PMC article.
Aberrant L-Fucose Accumulation and Increased Core Fucosylation Are Metabolic Liabilities in Mesenchymal Glioblastoma.
Pieri V, Gallotti AL, Drago D, Cominelli M, Pagano I, Conti V, Valtorta S, Coliva A, Lago S, Michelatti D, Massimino L, Ungaro F, Perani L, Spinelli A, Castellano A, Falini A, Zippo A, Poliani PL, Moresco RM, Andolfo A, Galli R. Pieri V, et al. Among authors: galli r. Cancer Res. 2023 Jan 18;83(2):195-218. doi: 10.1158/0008-5472.CAN-22-0677. Cancer Res. 2023. PMID: 36409826
Gene therapy of experimental brain tumors using neural progenitor cells.
Benedetti S, Pirola B, Pollo B, Magrassi L, Bruzzone MG, Rigamonti D, Galli R, Selleri S, Di Meco F, De Fraja C, Vescovi A, Cattaneo E, Finocchiaro G. Benedetti S, et al. Among authors: galli r. Nat Med. 2000 Apr;6(4):447-50. doi: 10.1038/74710. Nat Med. 2000. PMID: 10742153
Brain tumour stem cells.
Vescovi AL, Galli R, Reynolds BA. Vescovi AL, et al. Among authors: galli r. Nat Rev Cancer. 2006 Jun;6(6):425-36. doi: 10.1038/nrc1889. Nat Rev Cancer. 2006. PMID: 16723989 Review.
393 results