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HSP25 Vaccination Attenuates Atherogenesis via Upregulation of LDLR Expression, Lowering of PCSK9 Levels and Curbing of Inflammation.
Chen YX, Shi C, Deng J, Diao C, Maarouf N, Rosin M, Shrivastava V, Hu AA, Bharadwa S, Adijiang A, Ulke-Lemee A, Gwilym B, Hellmich A, Malozzi C, Batulan Z, Dean JLE, Ramirez FD, Liu J, Gerthoffer WT, O'Brien ER. Chen YX, et al. Among authors: shi c. Arterioscler Thromb Vasc Biol. 2021 Jun;41(6):e338-e353. doi: 10.1161/ATVBAHA.121.315933. Epub 2021 Apr 1. Arterioscler Thromb Vasc Biol. 2021. PMID: 33792343 Free PMC article.
Heat shock protein 27-derived atheroprotection involves reverse cholesterol transport that is dependent on GM-CSF to maintain ABCA1 and ABCG1 expression in ApoE-/- mice.
Pulakazhi Venu VK, Adijiang A, Seibert T, Chen YX, Shi C, Batulan Z, O'Brien ER. Pulakazhi Venu VK, et al. Among authors: shi c. FASEB J. 2017 Jun;31(6):2364-2379. doi: 10.1096/fj.201601188R. Epub 2017 Feb 23. FASEB J. 2017. PMID: 28232480
-Pulakazhi Venu, V. K., Adijiang, A., Seibert, T., Chen, Y.-X., Shi, C., Batulan, Z., O'Brien, E. R. Heat shock protein 27-derived atheroprotection involves reverse cholesterol transport that is dependent on GM-CSF to maintain ABCA1 and ABCG1 expression in ApoE(-/-) …
-Pulakazhi Venu, V. K., Adijiang, A., Seibert, T., Chen, Y.-X., Shi, C., Batulan, Z., O'Brien, E. R. Heat shock protein 27-der …
Characterization of heat shock protein 27 in extracellular vesicles: a potential anti-inflammatory therapy.
Shi C, Ulke-Lemée A, Deng J, Batulan Z, O'Brien ER. Shi C, et al. FASEB J. 2019 Feb;33(2):1617-1630. doi: 10.1096/fj.201800987R. Epub 2018 Sep 6. FASEB J. 2019. PMID: 30188755

Studies using THP-1 and human embryonic kidney cells show that HSP27-laden exosomes significantly stimulated NF-kappaB activation ( P < 0.001) and release of IL-10 ( P < 0.0001), suggesting that HSP27 may be important exosomal cargo with beneficial anti-inflammatory effects

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Studies using THP-1 and human embryonic kidney cells show that HSP27-laden exosomes significantly stimulated NF-kappaB activation ( P < 0

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Heat shock protein-27 attenuates foam cell formation and atherogenesis by down-regulating scavenger receptor-A expression via NF-κB signaling.
Raizman JE, Chen YX, Seibert T, Hibbert B, Cuerrier CM, Salari S, Zhao X, Hu T, Shi C, Ma X, Simard T, Caravaggio J, Rayner K, Bowdish D, Moore K, O'Brien ER. Raizman JE, et al. Among authors: shi c. Biochim Biophys Acta. 2013 Dec;1831(12):1721-8. doi: 10.1016/j.bbalip.2013.07.015. Epub 2013 Aug 11. Biochim Biophys Acta. 2013. PMID: 23939398
4-Phenylbutyrate protects against atherosclerotic lesion growth by increasing the expression of HSP25 in macrophages and in the circulation of Apoe-/- mice.
Lynn EG, Lhoták Š, Lebeau P, Byun JH, Chen J, Platko K, Shi C, O'Brien ER, Austin RC. Lynn EG, et al. Among authors: shi c. FASEB J. 2019 Jul;33(7):8406-8422. doi: 10.1096/fj.201802293RR. Epub 2019 Apr 9. FASEB J. 2019. PMID: 30964709
G., Lhotak, S., Lebeau, P., Byun, J. H., Chen, J., Platko, K., Shi, C., O'Brien, E. R., Austin, R. C. 4-Phenylbutyrate protects against atherosclerotic lesion growth by increasing the expression of HSP25 in macrophages and in the circulation of Apoe(-/-) mice …
G., Lhotak, S., Lebeau, P., Byun, J. H., Chen, J., Platko, K., Shi, C., O'Brien, E. R., Austin, R. C. 4-Phenylbutyrate …
Recombinant heat shock protein 27 (HSP27/HSPB1) protects against cadmium-induced oxidative stress and toxicity in human cervical cancer cells.
Alvarez-Olmedo DG, Biaggio VS, Koumbadinga GA, Gómez NN, Shi C, Ciocca DR, Batulan Z, Fanelli MA, O'Brien ER. Alvarez-Olmedo DG, et al. Among authors: shi c. Cell Stress Chaperones. 2017 May;22(3):357-369. doi: 10.1007/s12192-017-0768-y. Epub 2017 Mar 24. Cell Stress Chaperones. 2017. PMID: 28337643 Free PMC article.
7,724 results