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Design, Synthesis, and Structure-Activity Relationships Study of N-Pyrimidyl/Pyridyl-2-thiazolamine Analogues as Novel Positive Allosteric Modulators of M3 Muscarinic Acetylcholine Receptor.
Tanaka H, Akaiwa M, Negoro K, Kawaminami E, Mihara H, Fuji H, Okimoto R, Ino K, Ishizu K, Takahashi T. Tanaka H, et al. Among authors: takahashi t. Chem Pharm Bull (Tokyo). 2021;69(4):360-373. doi: 10.1248/cpb.c20-00877. Chem Pharm Bull (Tokyo). 2021. PMID: 33790081 Free article.
Highly selective peroxisome proliferator-activated receptor δ (PPARδ) modulator demonstrates improved safety profile compared to GW501516.
Lagu B, Kluge AF, Goddeeris MM, Tozzo E, Fredenburg RA, Chellur S, Senaiar RS, Jaleel M, Babu DRK, Tiwari NK, Takahashi T, Patane MA. Lagu B, et al. Among authors: takahashi t. Bioorg Med Chem Lett. 2018 Feb 1;28(3):533-536. doi: 10.1016/j.bmcl.2017.11.006. Epub 2017 Nov 4. Bioorg Med Chem Lett. 2018. PMID: 29275935
Novel highly selective peroxisome proliferator-activated receptor δ (PPARδ) modulators with pharmacokinetic properties suitable for once-daily oral dosing.
Lagu B, Kluge AF, Fredenburg RA, Tozzo E, Senaiar RS, Jaleel M, Panigrahi SK, Tiwari NK, Krishnamurthy NR, Takahashi T, Patane MA. Lagu B, et al. Among authors: takahashi t. Bioorg Med Chem Lett. 2017 Dec 1;27(23):5230-5234. doi: 10.1016/j.bmcl.2017.10.037. Epub 2017 Oct 27. Bioorg Med Chem Lett. 2017. PMID: 29103972
Selective PPARδ Modulators Improve Mitochondrial Function: Potential Treatment for Duchenne Muscular Dystrophy (DMD).
Lagu B, Kluge AF, Tozzo E, Fredenburg R, Bell EL, Goddeeris MM, Dwyer P, Basinski A, Senaiar RS, Jaleel M, Tiwari NK, Panigrahi SK, Krishnamurthy NR, Takahashi T, Patane MA. Lagu B, et al. Among authors: takahashi t. ACS Med Chem Lett. 2018 Jul 31;9(9):935-940. doi: 10.1021/acsmedchemlett.8b00287. eCollection 2018 Sep 13. ACS Med Chem Lett. 2018. PMID: 30258544 Free PMC article.
Observation of edge states derived from topological helix chains.
Nakayama K, Tokuyama A, Yamauchi K, Moriya A, Kato T, Sugawara K, Souma S, Kitamura M, Horiba K, Kumigashira H, Oguchi T, Takahashi T, Segawa K, Sato T. Nakayama K, et al. Among authors: takahashi t. Nature. 2024 Jun 5. doi: 10.1038/s41586-024-07484-z. Online ahead of print. Nature. 2024. PMID: 38839966
Final analyses of the prospective controlled trial on the efficacy of uracil and tegafur/leucovorin as an adjuvant treatment for stage II colon cancer with risk factors for recurrence using propensity score-based methods (JFMC46-1201).
Ogata Y, Sadahiro S, Sakamoto K, Tsuchiya T, Takahashi T, Ohge H, Sato T, Kondo K, Baba H, Itabashi M, Ikeda M, Hamada M, Maeda K, Masuko H, Takahashi K, Kusano M, Hyodo I, Sakamoto J, Taguri M, Morita S. Ogata Y, et al. Among authors: takahashi t. Int J Clin Oncol. 2024 Jun 4. doi: 10.1007/s10147-024-02565-5. Online ahead of print. Int J Clin Oncol. 2024. PMID: 38833114
The efficacy and tolerability of proteoglycan F in the treatment of knee osteoarthritis: A prospective, randomized, double-blind controlled trial.
Thanh Vu HT, Thu Nguyen HT, Hoai Nguyen TT, Nguyen TX, Nguyen TN, Nguyen AL, Nguyen LTH, La HT, Thu Vu HT, Bui QTT, Nghiem TN, Iddamalgoda A, Ito K, Takahashi T, Le TD, Pham T, Nguyen AT. Thanh Vu HT, et al. Among authors: takahashi t. Osteoarthr Cartil Open. 2024 May 9;6(3):100483. doi: 10.1016/j.ocarto.2024.100483. eCollection 2024 Sep. Osteoarthr Cartil Open. 2024. PMID: 38832051 Free PMC article. Clinical Trial.
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