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A Francisella tularensis live vaccine strain (LVS) mutant with a deletion in capB, encoding a putative capsular biosynthesis protein, is significantly more attenuated than LVS yet induces potent protective immunity in mice against F. tularensis challenge.
Jia Q, Lee BY, Bowen R, Dillon BJ, Som SM, Horwitz MA. Jia Q, et al. Infect Immun. 2010 Oct;78(10):4341-55. doi: 10.1128/IAI.00192-10. Epub 2010 Jul 19. Infect Immun. 2010. PMID: 20643859 Free PMC article.
A heterologous prime-boost vaccination strategy comprising the Francisella tularensis live vaccine strain capB mutant and recombinant attenuated Listeria monocytogenes expressing F. tularensis IglC induces potent protective immunity in mice against virulent F. tularensis aerosol challenge.
Jia Q, Bowen R, Sahakian J, Dillon BJ, Horwitz MA. Jia Q, et al. Infect Immun. 2013 May;81(5):1550-61. doi: 10.1128/IAI.01013-12. Epub 2013 Feb 25. Infect Immun. 2013. PMID: 23439306 Free PMC article.
Technology transfer of oil-in-water emulsion adjuvant manufacturing for pandemic influenza vaccine production in Romania: Preclinical evaluation of split virion inactivated H5N1 vaccine with adjuvant.
Stavaru C, Onu A, Lupulescu E, Tucureanu C, Rasid O, Vlase E, Coman C, Caras I, Ghiorghisor A, Berbecila L, Tofan V, Bowen RA, Marlenee N, Hartwig A, Bielefeldt-Ohmann H, Baldwin SL, Van Hoeven N, Vedvick TS, Huynh C, O'Hara MK, Noah DL, Fox CB. Stavaru C, et al. Among authors: bowen ra. Hum Vaccin Immunother. 2016 Apr 2;12(4):1009-26. doi: 10.1080/21645515.2015.1111495. Epub 2015 Nov 30. Hum Vaccin Immunother. 2016. PMID: 26618392 Free PMC article.
310 results