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Co-targeting of HDAC, PI3K, and Bcl-2 results in metabolic and transcriptional reprogramming and decreased mitochondrial function in acute myeloid leukemia.
Hege Hurrish K, Qiao X, Li X, Su Y, Carter J, Ma J, Kalpage HA, Hüttemann M, Edwards H, Wang G, Kim S, Dombkowski A, Bao X, Li J, Taub JW, Ge Y. Hege Hurrish K, et al. Among authors: kalpage ha. Biochem Pharmacol. 2022 Nov;205:115283. doi: 10.1016/j.bcp.2022.115283. Epub 2022 Oct 5. Biochem Pharmacol. 2022. PMID: 36208684 Free PMC article.
Tissue-specific regulation of cytochrome c by post-translational modifications: respiration, the mitochondrial membrane potential, ROS, and apoptosis.
Kalpage HA, Bazylianska V, Recanati MA, Fite A, Liu J, Wan J, Mantena N, Malek MH, Podgorski I, Heath EI, Vaishnav A, Edwards BF, Grossman LI, Sanderson TH, Lee I, Hüttemann M. Kalpage HA, et al. FASEB J. 2019 Feb;33(2):1540-1553. doi: 10.1096/fj.201801417R. Epub 2018 Sep 17. FASEB J. 2019. PMID: 30222078 Free PMC article. Review.
We examine the role of Cyt c PTMs, including phosphorylation, acetylation, methylation, nitration, nitrosylation, and sulfoxidation and consider their potential biological significance by evaluating their stoichiometry.-Kalpage, H. A., Bazylianska, V., Recanati, M. …
We examine the role of Cyt c PTMs, including phosphorylation, acetylation, methylation, nitration, nitrosylation, and sulfoxidation and cons …
Cotargeting of Mitochondrial Complex I and Bcl-2 Shows Antileukemic Activity against Acute Myeloid Leukemia Cells Reliant on Oxidative Phosphorylation.
Liu F, Kalpage HA, Wang D, Edwards H, Hüttemann M, Ma J, Su Y, Carter J, Li X, Polin L, Kushner J, Dzinic SH, White K, Wang G, Taub JW, Ge Y. Liu F, et al. Among authors: kalpage ha. Cancers (Basel). 2020 Aug 24;12(9):2400. doi: 10.3390/cancers12092400. Cancers (Basel). 2020. PMID: 32847115 Free PMC article.
17 results