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Folding of CFTR is predominantly cotranslational.
Kleizen B, van Vlijmen T, de Jonge HR, Braakman I. Kleizen B, et al. Among authors: braakman i. Mol Cell. 2005 Oct 28;20(2):277-87. doi: 10.1016/j.molcel.2005.09.007. Mol Cell. 2005. PMID: 16246729 Free article.
CFTR Folding Consortium: methods available for studies of CFTR folding and correction.
Peters KW, Okiyoneda T, Balch WE, Braakman I, Brodsky JL, Guggino WB, Penland CM, Pollard HB, Sorscher EJ, Skach WR, Thomas PJ, Lukacs GL, Frizzell RA. Peters KW, et al. Among authors: braakman i. Methods Mol Biol. 2011;742:335-53. doi: 10.1007/978-1-61779-120-8_20. Methods Mol Biol. 2011. PMID: 21547742 Free PMC article.
Slowing ribosome velocity restores folding and function of mutant CFTR.
Oliver KE, Rauscher R, Mijnders M, Wang W, Wolpert MJ, Maya J, Sabusap CM, Kesterson RA, Kirk KL, Rab A, Braakman I, Hong JS, Hartman JL 4th, Ignatova Z, Sorscher EJ. Oliver KE, et al. Among authors: braakman i. J Clin Invest. 2019 Dec 2;129(12):5236-5253. doi: 10.1172/JCI124282. J Clin Invest. 2019. PMID: 31657788 Free PMC article.
Clinical and molecular characterization of the R751L-CFTR mutation.
Haq IJ, Althaus M, Gardner AI, Yeoh HY, Joshi U, Saint-Criq V, Verdon B, Townshend J, O'Brien C, Ben-Hamida M, Thomas M, Bourke S, van der Sluijs P, Braakman I, Ward C, Gray MA, Brodlie M. Haq IJ, et al. Among authors: braakman i. Am J Physiol Lung Cell Mol Physiol. 2021 Feb 1;320(2):L288-L300. doi: 10.1152/ajplung.00137.2020. Epub 2020 Dec 9. Am J Physiol Lung Cell Mol Physiol. 2021. PMID: 33296276 Free PMC article.
Co-Translational Folding of the First Transmembrane Domain of ABC-Transporter CFTR is Supported by Assembly with the First Cytosolic Domain.
Kleizen B, van Willigen M, Mijnders M, Peters F, Grudniewska M, Hillenaar T, Thomas A, Kooijman L, Peters KW, Frizzell R, van der Sluijs P, Braakman I. Kleizen B, et al. Among authors: braakman i. J Mol Biol. 2021 Jun 25;433(13):166955. doi: 10.1016/j.jmb.2021.166955. Epub 2021 Mar 24. J Mol Biol. 2021. PMID: 33771570 Free article.
101 results