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Integrating Systems and Synthetic Biology to Understand and Engineer Microbiomes.
Annu Rev Biomed Eng. 2021 Jul 13;23:169-201. doi: 10.1146/annurev-bioeng-082120-022836. Epub 2021 Mar 29.
Annu Rev Biomed Eng. 2021.
PMID: 33781078
Free PMC article.
Review.
Nature's recyclers: anaerobic microbial communities drive crude biomass deconstruction.
Lillington SP, Leggieri PA, Heom KA, O'Malley MA.
Lillington SP, et al. Among authors: leggieri pa.
Curr Opin Biotechnol. 2020 Apr;62:38-47. doi: 10.1016/j.copbio.2019.08.015. Epub 2019 Oct 5.
Curr Opin Biotechnol. 2020.
PMID: 31593910
Review.
Item in Clipboard
Experimentally Validated Reconstruction and Analysis of a Genome-Scale Metabolic Model of an Anaerobic Neocallimastigomycota Fungus.
Wilken SE, Monk JM, Leggieri PA, Lawson CE, Lankiewicz TS, Seppälä S, Daum CG, Jenkins J, Lipzen AM, Mondo SJ, Barry KW, Grigoriev IV, Henske JK, Theodorou MK, Palsson BO, Petzold LR, O'Malley MA.
Wilken SE, et al. Among authors: leggieri pa.
mSystems. 2021 Feb 16;6(1):e00002-21. doi: 10.1128/mSystems.00002-21.
mSystems. 2021.
PMID: 33594000
Free PMC article.
Item in Clipboard
Non-destructive quantification of anaerobic gut fungi and methanogens in co-culture reveals increased fungal growth rate and changes in metabolic flux relative to mono-culture.
Leggieri PA, Kerdman-Andrade C, Lankiewicz TS, Valentine MT, O'Malley MA.
Leggieri PA, et al.
Microb Cell Fact. 2021 Oct 18;20(1):199. doi: 10.1186/s12934-021-01684-2.
Microb Cell Fact. 2021.
PMID: 34663313
Free PMC article.
Item in Clipboard
Biofilm disruption enhances growth rate and carbohydrate-active enzyme production in anaerobic fungi.
Leggieri PA, Valentine MT, O'Malley MA.
Leggieri PA, et al.
Bioresour Technol. 2022 Aug;358:127361. doi: 10.1016/j.biortech.2022.127361. Epub 2022 May 21.
Bioresour Technol. 2022.
PMID: 35609749
Free article.
Item in Clipboard
Lignin deconstruction by anaerobic fungi.
Lankiewicz TS, Choudhary H, Gao Y, Amer B, Lillington SP, Leggieri PA, Brown JL, Swift CL, Lipzen A, Na H, Amirebrahimi M, Theodorou MK, Baidoo EEK, Barry K, Grigoriev IV, Timokhin VI, Gladden J, Singh S, Mortimer JC, Ralph J, Simmons BA, Singer SW, O'Malley MA.
Lankiewicz TS, et al. Among authors: leggieri pa.
Nat Microbiol. 2023 Apr;8(4):596-610. doi: 10.1038/s41564-023-01336-8. Epub 2023 Mar 9.
Nat Microbiol. 2023.
PMID: 36894634
Free PMC article.
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Continuous culture of anaerobic fungi enables growth and metabolic flux tuning without use of genetic tools.
Leggieri PA, Blair EM, Lankiewicz TS, O'Malley MA.
Leggieri PA, et al.
Bioresour Technol. 2024 Jan;391(Pt A):129854. doi: 10.1016/j.biortech.2023.129854. Epub 2023 Oct 18.
Bioresour Technol. 2024.
PMID: 37863334
Free article.
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