Oxidant sensor cation channel TRPM2 regulates neutrophil extracellular trap formation and protects against pneumoseptic bacterial infection.
Tripathi JK, Sharma A, Sukumaran P, Sun Y, Mishra BB, Singh BB, Sharma J.
Tripathi JK, et al. Among authors: sharma a, sharma j.
FASEB J. 2018 Jun 15;32(12):fj201800605. doi: 10.1096/fj.201800605. Online ahead of print.
FASEB J. 2018.
PMID: 29906250
Free PMC article.
These results identify a key role of TRPM2 in regulating NET formation by exogenous ROS via AMPK/p38 activation and autophagy machinery, as well as a protective antimicrobial role of TRPM2 in pneumonic bacterial infection.-Tripathi, J. K., Sharma, A., Sukumaran, P., …
These results identify a key role of TRPM2 in regulating NET formation by exogenous ROS via AMPK/p38 activation and autophagy machinery, as …